In this episode, Amy and Nikki discuss the impact of proton pump inhibitors (PPIs) on gut health, specifically focusing on their relation to the development of irritable bowel syndrome (IBS). They cover what PPIs are, common brands, and why they are prescribed. The conversation highlights the controversy surrounding PPIs, noting that while they can be necessary for certain conditions like gastritis and esophagitis, they are often overprescribed or used inappropriately, leading to various health risks.

They emphasize the importance of gradual tapering off PPIs to avoid rebound reflux and discuss the potential for PPIs to cause dysbiosis in the small intestine. They also mention strategies for mitigating the negative effects of PPIs, such as probiotics and prokinetics, and underline the importance of balancing the benefits and risks of these medications.

00:00 Welcome Back and New Year Greetings
00:19 Introduction to PPIs
02:23 Controversies and Risks of PPIs
03:32 PPIs and IBS Connection
05:29 Proper Use and Tapering Off PPIs
09:49 Prevalence and Impact of PPI Use
11:38 Understanding Stomach Acid and Microbiome
15:37 Microbiology and Real-World Applications
19:09 Understanding Stomach pH and PPIs
19:43 Impact of PPIs on the Microbiome
20:47 Studies Linking PPIs to IBS
25:14 Mitigation Strategies for PPI-Induced IBS
31:18 Realistic Expectations for Managing IBS and Autoimmunity
35:46 Concluding Thoughts and Future Topics

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Nikki's Info:
- Youtube Channel: https://www.youtube.com/c/TriangleHolisticGutHealth
- Instagram: @Gut.Microbiome.Queen
- FODMAP Freedom in 90 Days: https://www.fodmapfreedom.com/enroll
- Private Appts: https://infinityholistichealth.com/

Amy's Info:
- Practice: https://sibodiaries.com/
- Instagram: @Amy_Hollenkamp_RD