Episodes

  • Episode 590 - Waen Shepherd
    Jan 4 2026

    Comedian/actor/writer/composer Waen Shepherd (@waenshep) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange, the biology of elves, the best chocolate chip cookie recipe, a runaway supermassive black hole, a lemon-shaped exoplanet and the music of Gary Wilson.

    Show More Show Less
    1 hr and 13 mins
  • Episode 589 - Chris Duffy
    Dec 28 2025

    Comedian/host/author Chris Duffy (@chrisiduffy) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy, his radio show/podcast You're The Expert, his TED podcast How To Be a Better Human, the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy, prescribing standup to improve mental health, training Swedish crows to pick up cigarette butts and a frozen worm revived after 46,000 years.

    Show More Show Less
    1 hr and 10 mins
  • Episode 588 - Buddy Fitzpatrick
    Dec 16 2025

    Comedian Buddy Fitzpatrick (@buddycomic) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry, the rooms of Madonna Inn, ladyfingers, manmade fire from 350,000 years earlier than previously thought, monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation.

    Show More Show Less
    1 hr and 18 mins
  • Episode 587 - Adam Burke
    Dec 9 2025

    Comedian Adam Burke (@atpburke) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican, debunking the Stanford Prison Experiment, classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey, AIs that believe themselves to be more rational than humans, 3D printing with a mosquito proboscis, Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show.

    Show More Show Less
    1 hr and 24 mins
  • Episode 586 - Ophira Eisenberg
    Nov 28 2025

    Comedian/writer/NPR host Ophira Eisenberg (@ophirae) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke, her upcoming special produced by Lewis Black, the effect of venting on anger, a rage room show Andy worked on, why you should leave uncontacted tribes alone, the wombat-thief influencer and why you should speak up to seagulls.

    Show More Show Less
    1 hr and 25 mins
  • Episode 585 - Jeff Zenisek
    Nov 14 2025

    Comedian Jess Zenisek (@jeffzenisek) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard, Jeff's hair care regimen, a tiny tyrannosaur, a better rock-paper-scissors strategy, gray hair's relationship to cancer, the worst music to play during sex and the banger Parked By The Lake.

    Show More Show Less
    1 hr and 12 mins
  • Episode 584 - Drew Droege
    Nov 10 2025

    Comedian/playwright Drew Droege (@drew_droege) joins Matt, Jesse and Andy to talk about his new off-Broadway play Messy White Gays, X-ray NBA poker fraud and why birds sing after a solar eclipse.

    Show More Show Less
    52 mins
  • Episode 583 - Mehran Khaghani
    Oct 29 2025

    Wonderful NY comic Mehran Khagani (@themehran) joins Jesse and Matt to talk about escaping from Iran, working at the Harvard School of Public Health, hyrax butt drag fossil marks, Canadian heart transplants and the most pristine star in the universe!

    In the patreon bonus we get into penguin micronaps.

    Click here to support Probably Science via Patreon

    Show More Show Less
    54 mins