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Pharmacology News

Pharmacology News

By: Circle Of Insight Productions
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 Join Dr. Carlos on “Pharmacology Insights,” your source for the latest research and news on pharmacology, medications, and street drugs. Each episode delves into cutting-edge discoveries, practical applications, and the evolving landscape of both legal and illicit substances. Gain a deeper understanding of how drugs work, their impacts on health, and the latest trends in medication and drug use. Tune in for expert analysis and insightful discussions that keep you informed on all things pharmacological.Copyright Circle Of Insight Productions Economics Hygiene & Healthy Living Physical Illness & Disease Science Social Sciences
Episodes
  • Antidepressant Withdrawal: 50% of Long-Term Users Suffer? Shocking JAMA Study vs Real-World Reality Exposed

    Antidepressant Withdrawal: 50% of Long-Term Users Suffer? Shocking JAMA Study vs Real-World Reality Exposed
    Apr 27 2026
    Psychiatrists are clashing over antidepressant withdrawal: clinic data shows up to 50% of long-term SSRI/SRI users face severe symptoms, while a major 2025 JAMA Psychiatry meta-analysis claims they’re usually mild and brief. We break down both sides, expose the massive limitations in the studies, and reveal what this means for millions on these drugs.
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    10 mins
  • Metabolic Brake or Muscle Catalyst? The Pharmacokinetics of GLP-1 Muscle Loss

    Metabolic Brake or Muscle Catalyst? The Pharmacokinetics of GLP-1 Muscle Loss
    Apr 26 2026
    While GLP-1 receptor agonists are not inherently "muscle-toxic," the rapid metabolic shift they induce can lead to a catabolic state that consumes lean tissue. In this episode, we dive into the pharmacology of semaglutide and tirzepatide, examining how slowed gastric emptying and blunted appetite signals impact the leucine threshold required for muscle protein synthesis. We explore the "glucose-alanine cycle," the role of myostatin inhibitors in future drug pipelines, and how adjusted protein dosing ($1.2$ to $1.6\text{ g/kg}$) can act as a pharmacological safeguard against sarcopenia.
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    5 mins
  • Ibogaine: Miracle Cure or Medical Gamble? The Truth Behind a Controversial Psychedelic

    Ibogaine: Miracle Cure or Medical Gamble? The Truth Behind a Controversial Psychedelic
    Apr 20 2026
    This episode explores ibogaine as a controversial psychedelic treatment for addiction, examining its reported effects on opioid withdrawal, cravings, and psychological insight alongside serious cardiac and neurological risks. It provides a balanced, evidence-based analysis of ibogaine research, including limitations such as lack of randomized trials, selection bias, and short-term outcome data. Ideal for listeners interested in addiction science, mental health innovation, neuroscience, and the risks and promise of emerging psychedelic therapies.
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    7 mins
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