Origins - Inside Venture Capital, Hosted by a GP and an LP cover art

Origins - Inside Venture Capital, Hosted by a GP and an LP

Origins - Inside Venture Capital, Hosted by a GP and an LP

By: OpenLP from Sapphire Partners
Listen for free

About this listen

Hosted by a General Partner (GP) and a Limited Partner (LP), Origins dives into the venture capital ecosystem to learn how the people behind the money make decisions: How LPs choose VC funds to invest in, what drives performance in venture, the dos and don'ts of fundraising, what founders/entrepreneurs/CEOs need to do to raise a Seed, Series A and beyond, what it takes to go from emerging manager to franchise VC, and the latest private market trends and dynamics shaping the investment ecosystem. Origins is co-hosted by GP Nick Chirls and LP Beezer Clarkson.OpenLP from Sapphire Partners Economics Personal Finance
Episodes
  • Backing Outliers in Venture with Sunil Dhaliwal & Mike Dauber
    Aug 12 2025

    Sunil Dhaliwal founded Amplify in 2012, and was joined by his longtime friend and colleague Mike Dauber in 2014. Beginning as one of the first solo GP, early-stage, sector-focused funds, Amplify has now grown to a team of 9 partners investing in the next generation of applications tools and platforms for developers, data teams, and ML engineers focused on AI, cloud infrastructure, and data security. Mike and Sunil sit down with Beezer Clarkson, Partner at Sapphire Partners, to discuss their strategy of building for outliers, shaping founders into leaders, and making it easy for their GPs to back non-consensus companies. They also unpack their recent $900 million raise and their first dedicated biotech fund, Amplify Bio.


    Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners

    Learn more about OpenLP: openlp.vc

    Learn more about Asylum Ventures: asylum.vc

    Learn more about Amplify: amplifypartners.com


    For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc


    CHAPTERS:

    0:00 Welcome to Origins

    2:17 The Origins of Amplify

    5:21 Eliminating the Need for “Mr. Business”

    10:25 Building Amplify for Outliers

    25:08 Being Technical VCs in the Age of AI

    28:47 Amplify Bio

    36:19 Has Venture Actually Changed At All?

    Show More Show Less
    41 mins
  • Minisode: Are Major Incumbents Finally at Risk in the Age of AI?
    Jul 22 2025

    Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson, LP at Sapphire Partners and co-founder of OpenLP, dig into their recent conversation with Will Manidis, SVP at Veradigm AI. They discuss the risks AI introduces to tech incumbents, and its potential to reshape both the healthcare system and improve patient outcomes.


    Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners

    Learn more about OpenLP: openlp.vc

    Learn more about Asylum Ventures: asylum.vc

    Learn more about Veradigm: veradigm.com/


    Subscribe to the OpenLP newsletter for a monthly roundup of the latest venture insights, including the newest Origins episodes, delivered straight to your inbox.


    CHAPTERS:

    (0:00) Welcome to Origins

    (1:41) Humor in Venture?

    (3:17) Are Incumbents Finally At Risk?

    (6:25) How Extremely Online is Nick?

    Show More Show Less
    8 mins
  • Merchant Banks: Venture’s Next Act with Will Manidis
    Jul 8 2025

    Before he sold his company to Veradigm, Will Manidis’s Science.io developed an AI model that allowed doctors to translate mountains of medical documents into usable data to improve patient outcomes. Today Will is the SVP of AI at Veradigm, and he sits down with Nick and Beezer to discuss how AI is impacting healthcare, how we can develop health systems with better outcomes, and what the future of venture might look like when compared to traditional merchant banking.


    Learn more about Sapphire Partners: sapphireventures.com/sapphire-partners

    Learn more about OpenLP: openlp.vc

    Learn more about Asylum Ventures: asylum.vc

    Learn more about Veradigm: veradigm.com/


    For a monthly roundup of the latest venture insights, including the newest Origins episodes, subscribe to the OpenLP newsletter – delivered straight to your inbox: subscribe.openlp.vc


    CHAPTERS:

    (0:00) Welcome to Origins

    (2:01) Human vs. AI Content (Specifically Podcasts)

    (6:18) AI And the Future of Healthcare

    (17:55) Is Merchant Banking Venture’s Future?

    (25:17) When Does Venture Break?

    (32:42) “The Only Thing We Should Care About is the Shape of the Return Curve.”

    (37:24) “The Constraint Is No Longer Capital.”

    Show More Show Less
    44 mins
No reviews yet
In the spirit of reconciliation, Audible acknowledges the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today.