Oprah sits down with Reese Witherspoon and Mindy Kaling, her co-stars from the film "A Wrinkle in Time," for a lively conversation about ambition, guardian angels, learning to say no, and the pressures women face in today's culture. Reese and Mindy discuss the hardest decisions they had to make in order to fulfill their destinies. Oprah says, "I'm so excited to have a conversation with such beautiful, innovative, powerful women." Directed by pioneer filmmaker Ava DuVernay, "A Wrinkle in Time" is adapted from Madeleine L'Engle's classic 1962 novel of the same name. The movie is about a young girl, Meg Murry, played by newcomer Storm Reid, who hops through time to rescue her father from an evil, universe-threatening force. Ava describes the story as a tapestry of "spirituality and self-empowerment." Disney's "A Wrinkle in Time" has its premiere in movie theaters on March 9, 2018.

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In a rare interview at his home on the Hawaiian island of Maui, cultural icon Ram Dass sits down with Oprah to discuss his role as a global spiritual teacher. Born in 1931 to a wealthy family outside of Boston, Richard Alpert was the star of his family. By age 27, he was an assistant professor at Harvard University, with a corner office. When another professor, Dr. Timothy Leary, moved into the office next door in 1959, Dr. Richard Alpert began the journey to become the man we know today as Ram Dass. Learn more about the psychedelic drug experiment that got them both fired, and the Indian guru who changed Ram's life forever.

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This episode originally aired February 7, 2018. Janet Mock, the transgender advocate, television host and New York Times best-selling author, discusses her powerful journey, the importance of speaking your truth, and becoming the person you know you were always meant to be. Janet offers insight into not only her transgender experience but also the importance of creating a vision for what is possible, and shows us how to see and accept one another through love. Janet's first memoir, "Redefining Realness," details her bold and inspiring perspective on being young, multicultural and transgender in America. Janet says her journey is similar to that of many people: "I think that we're all searching for the truth. I was constantly, as a person, going through this society trying to figure out who I was in relation to what people were telling me I should be. And so, for me, 'Redefining Realness' was about tapping into my most authentic self. Who am I to me?"

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