"Microbiome" is a buzzword these days--but many people don't know what it means. As we re-assess the lasting impact diet may have on our health, researchers are examining the role of gut health as possible causes for the dramatic uptick in colorectal cancer in young people. Katie Couric, founder of Katie Couric Media and Stand Up To Cancer, hosts an expert-led panel including Dr. Nancy You, a surgeon and director of the Young-Onset Colorectal Cancer Program at MD Anderson, Dr. Susan Bullman–an Associate Professor of Gastrointestinal Medical Oncology at The University of Texas MD Anderson Cancer Center, and Julie Smolyansky, CEO of Lifeway Foods, to discuss the impact of diet on the gut microbiome.

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Trump’s first 100 days? Worse than former congressman and “proud RINO” Adam Kinzinger ever imagined. He joins Katie for a bracing conversation about authoritarian creep, advice on Democratic Party messaging, why the next few years could be rougher than anyone’s ready for–and why blind optimism is useless, but keeping hope alive can galvanize the American people.

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In this heartfelt conversation, Katie sits down with the iconic Christie Brinkley or an intimate look at the moments that shaped her–from her bohemian days in Paris to the glitz of Studio 54, from the heights of modeling fame to unexpected heartbreak. With warmth, candor, and even a little singing, Christie opens up about a life lived in full technicolor--and now finally captured in her new memoir, Uptown Girl

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Project 2025. Maybe you’ve heard whispers about it. Maybe you’ve rolled your eyes. But David A. Graham read the whole thing—and he sat down with Katie to break down why this isn’t just rhetoric – it’s a roadmap already in motion. From privatizing weather data to rewinding civil rights gains, this playbook for Trump 2.0 is more extreme—and more possible—than you might think. In this episode, Graham walks us through the wildest parts of the plan, the men behind it, and why his book The Project might just be the most important one you read this year.

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Today, approximately 10,000 rare diseases collectively affect as many as 400 million people around the world, and women leaders have long been at the forefront of bringing awareness to these diseases and driving change. Katie Couric moderates a panel that includes Tania Simoncelli of Chan Zuckerberg Initiative, whose “Rare as One” campaign gives to rare disease researchers and support groups, Tara Zier who founded the Stiff Person Syndrome Research Foundation, Susan Dando of the Smith-Kingsmore Syndrome Foundation, and Dr. Christina Miyake, a researcher studying TANGO2 deficiency disorder. This panel will explore the resilience, determination, and ingenuity required to address the unique challenges in rare disease advocacy and research. Panelists will share their experiences in breaking barriers, leading patient-centered initiatives, and building collaborations that move the needle toward treatments and cures. #SponsoredbyCZI

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Rahm Emanuel has never been short on opinions—or jobs. He’s been a senior advisor to President Clinton, Chief of Staff to President Obama, a three-term Congressman, and Mayor of Chicago. Most recently, he served as the U.S. Ambassador to Japan. Now, he’s back stateside and full of ideas. From how to get the Democratic party back on track to protecting American democracy, Rahm joins Katie for a candid conversation—and may be the very first politician ever to honestly answer the question: are you running for president?

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They couldn’t—or wouldn’t—tell Biden it was time to go. Journalist Chris Whipple reveals the human drama behind the political failure, captured in his must-read book Uncharted.

Why did no one stop Joe Biden from running again? In this eye-opening interview, Chris and Katie pull back the curtain on the 2024 election, delving into the loyalty, fear, and misjudgment that shaped the race.

🎉 Big news! Next Question with Katie is nominated for Best News & Politics Podcast at the @TheWebbyAwards!

These awards are fan-voted—and we need YOUR help to bring it home 🏆🎧🗳️

Voting’s open now through April 17th. Hit that vote button 👉 https://vote.webbyawards.com/PublicVoting#/2025/podcasts/shows/music

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Season 11 of Next Question with Katie Couric is cutting through the noise. Tired of political headlines that feel like déjà vu? Wondering if you actually need to care about every controversy? This season, Katie’s asking the same questions—and talking to the people who have real answers. From political insiders to sharp-eyed journalists, she’s breaking down what’s worth your attention (and what’s not), with smarts, sanity, and even a little humor. Because none of us can be tuned in 24/7—but we can stay informed without losing our minds. Premiering April 10th, wherever you get your podcasts.

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