March Madness First Round Predictions | Full Bracket Reaction & Upset Picks
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MARCH MADNESS IS HERE! The bracket is officially set, and we’re reacting LIVE to every major matchup in the 2026 NCAA Division I Men's Basketball Tournament.
Spence and James break down the first round (Round of 64), analyzing matchups, spreads, coaching advantages, conference strength, and upset potential across every region.
We lock in the heavy favorites like Duke, UConn, Florida, Houston, Arizona, Gonzaga, Alabama, Michigan, Virginia, and Iowa State—but the real story is the upset picks
Upsets & Toss-Ups We Targeted:
TCU vs Ohio State (split decision)
Northern Iowa over St. John’s (Spence)
South Florida over Louisville (both)
UCF over UCLA (both)
Clemson over Iowa (both)
VCU over North Carolina (both)
High Point over Wisconsin (James)
Missouri over Miami (Spence)
St. Louis over Georgia (both)
Akron over Texas Tech (both)
Santa Clara over Kentucky (both)
We also highlight key weaknesses—like Iowa State’s free throw struggles—that could shake up your bracket.
👇 Join the conversation:
What’s your biggest upset in the first round? Who’s busting brackets this year?
🏆 Join the Big Game Energy Bracket Challenge
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00:00 Duke vs Siena Opener
00:53 Duke Dominance Breakdown
03:00 Ohio State vs TCU Tossup
04:29 St. John’s Upset Alert
06:31 Kansas vs Cal Baptist
08:05 South Florida Upset Pick
09:12 Michigan State & Izzo Impact
10:06 UCLA vs UCF Upset
11:48 UConn Rolls On
12:21 South Region Begins (Florida)
13:51 Clemson vs Iowa (8 vs 9)
14:51 Vanderbilt vs McNeese Drama
16:41 Nebraska vs Troy Pick
17:44 UNC vs VCU Upset
18:23 Illinois Advances
19:55 Saint Mary’s vs Texas A&M
20:59 Houston Advances Easily
21:36 15-Seed Upset History
22:48 West Region Favorites
23:40 Key 8/9 & 5/12 Picks
25:43 Bracket Challenge Plug
26:37 Arkansas, BYU, Gonzaga
29:31 Miami, Missouri, Purdue
31:58 Midwest Region Begins
33:54 Akron Upset Case
36:11 Tennessee & Virginia
38:59 Kentucky Fade Pick
40:32 Iowa State & Wrap