What if brain surgery could be performed without ever opening the skull? In this episode, Professor Ludvic Zrinzo, Head of the UCL Functional Neurosurgery Unit, reveals how cutting-edge techniques like deep brain stimulation, radiofrequency ablation, and focused ultrasound are transforming treatment for Parkinson’s disease, tremor, dystonia, OCD, depression, and Tourette’s syndrome. He explains the evolution of minimally invasive brain surgery, the importance of multidisciplinary care, and how personalised approaches are improving patient outcomes and quality of life.

You’ll also hear how research funded by the NIHR and MRC is shaping the future of neurological treatment and why patient choice is vital as new therapies emerge.

Key Topics Covered:

• Professor Zrinzo’s journey into neurosurgery and early influences
• Evolution of functional neurosurgery and multidisciplinary teamwork
• How deep brain stimulation improves Parkinson’s disease and movement disorders
• The rise of radiofrequency ablation and its benefits for tremor and mental health
• Breakthroughs in focused ultrasound as a non-invasive treatment
• The balance between technology, patient care, and ethical responsibility
• Funding and international collaboration in neurosurgery research

Follow the Queen Square In Focus Podcast to hear from the world’s leading neuroscientists and clinicians transforming brain health through innovation, research, and patient care.

Key Moments:

0:00 - Professor Zrinzo’s journey to functional neurosurgery

02:46 - The influence of technology and teamwork in modern neurosurgery

05:14 - What functional neurosurgery treats and why it matters

08:58 - Personalised treatment for Parkinson’s disease

11:57 - Advancements in deep brain stimulation

19:00 - The role of radiofrequency ablation

22:31 - Focused ultrasound and the future of non-invasive brain treatment

27:52 - Research directions and patient choice

31:58 - Funding and international collaboration