summary Dr. Carly Schissel, a powerhouse in the world of organic chemistry, discusses her role in designing molecules for drug discovery and development. She explains the importance of designing drugs that work in the right way with the right target and with the fewest side effects. Dr. Schissel shares her research on the chemical biology of peptides and the breakthroughs she has made in peptide delivery and modification. She also discusses the challenges and innovations in organic synthesis and the potential of machine learning in synthetic design. Dr. Schissel emphasizes the importance of mentorship and maintaining a balance between personal life and research. keywords organic chemistry, drug discovery, drug development, peptide delivery, chemical biology, synthetic design, machine learning, mentorship, work-life balance takeaways Designing drugs that work in the right way with the right target and with the fewest side effects is crucial in drug discovery and development. Peptides, which are small proteins, are powerful molecules that can be chemically modified and have the potential to be more drug-like. Machine learning can guide synthetic design and help in the discovery of new drugs and the prediction of toxic side effects. Mentorship and a supportive community are essential in the scientific research field. Maintaining a balance between personal life and research is important for overall well-being and perspective. titles The Power of Peptides in Drug Design Machine Learning in Synthetic Design Sound Bites "Creating tiny invisible machines that can fix problems at the cellular level." "Peptides are like small proteins that can be chemically modified and are powerful in targeting specific proteins." "Machine learning can predict better peptide sequences for drug delivery." Chapters 00:00 Introduction to Dr. Kali Seshel and Organic Chemistry 06:04 The Power of Peptides in Drug Design 08:00 Machine Learning in Synthetic Design 21:51 Challenges and Innovations in Research 32:58 Mentorship and Work-Life Balance

summary Rakesh Vashisht, Global Head of Customer Facing Execution Excellence at Boehringer Ingelheim, shares his 30-year journey in the pharmaceutical industry and discusses the evolving landscape of customer engagement. He emphasizes the importance of wisdom, earned through experience, and the need for passion, hard work, and a growth mindset in the industry. Rakesh highlights the challenges of information overload and the need for simplicity in customer engagement strategies. He also discusses the role of AI and technology in improving customer interactions and the importance of fostering a culture of innovation and accepting failure. keywords pharmaceutical industry, customer engagement, wisdom, passion, hard work, growth mindset, information overload, simplicity, AI, technology, innovation, failure Takeaways Wisdom in the pharmaceutical industry is earned through experience and challenges. Passion, hard work, and a growth mindset are crucial for success in the industry. Information overload is a challenge, and simplicity is key in customer engagement strategies. AI and technology can improve customer interactions and provide valuable insights. Fostering a culture of innovation and accepting failure is important for driving progress in the industry. Titles AI and Technology: Enhancing Customer Interactions in Pharma The Journey of Wisdom: 30 Years in the Pharmaceutical Industry Sound Bites "The true scarcity lies in wisdom." "Today when I think about customer landscape, my mind doesn't think face to face only. My mind is thinking on the channel." "I'm very optimistic that this challenge will be solved with new technology like artificial intelligence and machine learning." Chapters 00:00 Introduction 02:10 Rakesh's Career Journey 06:55 The Evolution of Customer Engagement 10:10 The Role of AI and Technology 15:03 Ensuring Compliance in Communication Channels 18:20 Adapting to the Changing Behavior of HCPs 19:47 Segmentation and Targeting Strategies 26:00 The Role of AI in Rep-Physician Interactions 29:51 Advice for Aspiring Professionals 34:09 Attributes for Success in the Pharma Industry 36:03 Personal Habits and Routines for Success 37:01 Fostering a Culture of Innovation 39:30 The Importance of Humility in Leadership 40:27 Closing Remarks

In this episode of Drug Diaries, Dr. Bede Portz discusses the field of condensate biology and its potential impact on drug discovery. Condensates are membrane-less structures in cells that provide an intermediate level of organization between randomness and membrane-encompassed organelles. By studying condensates, researchers can gain new insights into cellular processes and develop innovative approaches to treating complex diseases. One of the key challenges in drug discovery is targeting difficult proteins like the MYC protein, which plays a critical role in cancer growth and proliferation. Dewpoint, where Dr. Portz works, is focusing on developing treatments for ovarian cancer by targeting the MYC protein. The use of condensate science in drug discovery offers a new lens through which complex cellular processes can be understood and manipulated. Keywords condensate biology, drug discovery, cellular processes, MYC protein, ovarian cancer, condensate science Takeaways Condensates are membrane-less structures in cells that provide an intermediate level of organization between randomness and membrane-encompassed organelles. Studying condensates can provide new insights into cellular processes and offer innovative approaches to treating complex diseases. Targeting difficult proteins like the MYC protein, which plays a critical role in cancer growth and proliferation, is a key challenge in drug discovery. Dewpoint is focusing on developing treatments for ovarian cancer by targeting the MYC protein using condensate science. Condensate science offers a new lens through which complex cellular processes can be understood and manipulated in drug discovery. Titles Exploring the Fascinating World of Condensate Biology Rewriting the Rules of Drug Discovery with Condensate Science Sound Bites "Condensate science brings a paradigm shift to drug discovery." "Condensate science offers a new lens through which we can understand and manipulate complex cellular processes." "The MYC protein is a challenging target in cancer treatment." Chapters 00:00 Introduction to Condensate Biology 06:10 Condensate Science in Drug Discovery 08:37 Condensates as Integrating Nodes of Disease 31:43 The Future of Drug Development: Insights from Condensate Biology