In this episode, I speak with Dr. Sara Larivière, Assistant Professor at the Department of Nuclear Medicine and Radiobiology at Université de Sherbrooke. She is at the head of the SLIC (Sherbrooke Laboratory for Integrative Connectomics), holding a Canada Research Chair in Neuroimaging of Epilepsy. Dr. Larivière and I are friends and colleagues, having received our doctorate training at the same lab under the supervision of Dr. Boris Bernhardt, my first guest on the show.

Her lab integrates neuroimaging, computational statistics, machine learning, and pipeline engineering to advance knowledge of the human brain. By developing and deploying neuroinformatics and data science tools, her team investigates normal and atypical brain development, with the goal of enhancing personalized prognosis and therapies, ultimately aiming to shape public health policy.

In this instalment, Dr. Larivière and I break down a 2024 article we published in the Journal of the American Medical Association - Neurology, titled Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy. We discuss how accounting for widespread cortical dynamics in temporal lobe epilepsy (TLE) may inform novel therapeutic approaches that move beyond traditional subcortical targets.