How does Alzheimer’s disease really destroy memory?
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How does Alzheimer’s disease really destroy memory?
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About this listen
New research from Stanford University reveals a surprising mechanism: neurons may actively erase their own connections when triggered by amyloid beta and inflammation. In this video, we break down how two major Alzheimer’s pathways converge on a single receptor that drives synapse loss—and why this discovery could reshape future therapies.
Instead of focusing only on clearing amyloid plaques, this study suggests protecting synapses directly may be key to preserving memory.
🔬 What you’ll learn:
How amyloid beta and inflammation interact in Alzheimer’s
Why neurons are not just passive victims of the disease
What synapse pruning has to do with memory loss
How this discovery could influence next-generation Alzheimer’s drugs
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📌 Key Reference:
Brott et al., Proceedings of the National Academy of Sciences (PNAS), 2026
Wu Tsai Neurosciences Institute, Stanford University