In this episode of the Heart Failure Beat, Dr. Eric Adler of UC San Diego Health joins the show to discuss his landmark gene therapy trial for Danon disease, recently published in the New England Journal of Medicine. Dr. Adler recounts the powerful bedside-to-bench-to-bedside story that led to the development of a groundbreaking treatment for this severe, genetic cardiomyopathy. He explains the mechanics and evolution of gene therapy, its promise in treating monogenic heart failure syndromes, and the early but encouraging clinical outcomes—like dramatic reductions in troponins and heart mass. The episode also explores regulatory and safety challenges, delivery limitations, and the critical role of patient advocacy. Whether you’re a heart failure specialist or a translational researcher, this conversation offers compelling insights into the future of precision therapies in cardiology.

In this episode of Heart Failure Beat, Dr. Shashank Sinha—Medical Director of the CICU at Inova Fairfax—joins hosts Dr. Priya Umapathi and Dr. Michael Beasley to unpack the 2025 ACC Expert Consensus Statement on Cardiogenic Shock. Together, they explore the updated SHARC classification, staging systems, and the S.U.S.P.E.C.T. mnemonic for early recognition. Dr. Sinha shares practical insights on invasive hemodynamics, shock team composition, and new data on mechanical circulatory support. Plus, hear his “Top 10 Takeaways” for managing this complex and dynamic condition. Whether you work in a tertiary center or a community hospital, this episode delivers guidance for real-world care.

In this compelling episode of the HF Beat, join hosts Michael Beasley, MD and Priya Umapathi, MD and an esteemed panel of experts, including Dr. Eileen Hsich, Dr. Anu Lala, and Dr. Ilan Goldenberg, as they delve into the nuanced world of sex differences in heart failure. This conversation spans three key topics: identifying traditional and sex-specific risk factors for heart failure, addressing disparities in diagnosis and treatment, and exploring the implications of these differences on therapeutic responses and device-based interventions. Highlights include discussions on under diagnosis in women due to natriuretic peptide thresholds, CRT’s heightened benefits in women with non-ischemic cardiomyopathy, and the urgent need for inclusive clinical trials. With actionable insights and cutting-edge research, this episode equips heart failure clinicians with essential knowledge to better serve our heart failure patient population. Tune in to explore how advancing sex-specific research can transform heart failure care for all.