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GlycoCast, a journey of families, sugars and rare disorders

GlycoCast, a journey of families, sugars and rare disorders

By: Ivan Martinez Duncker
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About this listen

 Welcome to GlycoCast, the podcast where the sweet science of sugars meets the mysteries of medicine, and our shared humanity comes to life. We will focus on a journey of families, sugars and rare disorders called Congenital Disorders of Glycosylation. We'll bring you tales of struggle and perseverance, as we speak to families affected by CDGs, learn about their experiences, their challenges, and their achievements. We'll hear from the researchers on the front lines, unearthing the mysteries of CDGs, and the healthcare professionals who play a key role in managing these disorders.Ivan Martinez Duncker Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • CDG in Egypt with Dr. Sahar Sabry

    CDG in Egypt with Dr. Sahar Sabry
    Dec 20 2025

    We interview Dr. Sahar Sabry, a regional pioneer in Egypt that is advancing CDG diagnosis and specialized medical management.

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    40 mins
  • Understanding mosaicism and the case of SLC35A2-CDG

    Understanding mosaicism and the case of SLC35A2-CDG
    Sep 27 2025

    A podcast with our special guest Dr. Tracy Bedrosian from the Steven and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital where she heads the Bedrosian Lab

    Tracy has spent her career exploring how our brains develop and what happens when that process goes off track. Her research dives deep into genomics and a fascinating phenomenon called mosaicism that shapes brain development, influence conditions like epilepsy, and even intersects with rare genetic disorders like Congenital Disorders of Glycosylation (CDGs).

    In today’s conversation, we’ll unpack how her lab studies mosaic genetic variation and why this matters for understanding neurological complications of CDGs — especially SLC35A2-CDG, where cells struggle to transport UDP-galactose into the Golgi, the cellular factory where sugar chains, or glycans, are built.

    This episode is made possible through the support of CDG CARE, a nonprofit organization founded by parents seeking information and support for CDGs.
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    26 mins
  • Unlocking shared pathways and therapies for multiple CDGs

    Unlocking shared pathways and therapies for multiple CDGs
    Aug 22 2025

    What happens when cutting-edge science meets the curiosity of a new generation? In this episode of Glycocast, we sit down with Dr. Tamas Kozics and Dr. Irena Muffels from the Icahn School at Mount Sinai to explore their personal stories with Congenital Disorders of Glycosylation (CDG) and how their research is uncovering new insights into these metabolic diseases.

    Together, they walk us through their latest work, sharing how using huge amounts of biological data through advanced multi-omics approaches is untangling the complexity of CDGs and unraveling potential common treatments.

    This episode is not just about science—it’s about mentorship, collaboration, and the passion that drives researchers to keep moving forward, hand-in-hand with families, toward answers.

    The link to the science article: https://pubmed.ncbi.nlm.nih.gov/40743674/

    A family-friendly comprehensive summary will be avaiable soon at cdgcare.org
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    1 hr
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