Dr. Jesse Thompson joins Andrew and Tyler from his ski-town practice, Prime Medical Clinic, in Rossland, BC, where he's built something increasingly rare in medicine: a genuinely well-rounded practice spanning pain management, regenerative medicine, and aesthetics. What makes this conversation particularly valuable is Jesse's perspective on how these disciplines intersect—and his refreshingly honest take on why he doesn't need to hard-sell aesthetic treatments when patients are coming to him for comprehensive care.

The heart of this episode digs into integrative and functional medicine—not the Instagram-influencer version, but the practical reality of catching metabolic problems before they become disease categories. Jesse breaks down how measuring fasting insulin (rather than waiting for the conventional three-month blood sugar check) catches insulin resistance years earlier, and why the shift from "sick care to health care" is both desperately needed and financially complicated. He doesn't shy away from the peptide conversation either, offering a grounded perspective on BPC-157, GLP-1 agonists, and why half the people buying peptides online are wasting their money on contaminated compounds that do nothing—or worse.

The guys also tackle what it's like being a male injector in a female-dominated field (spoiler: having your wife as your practice partner solves a lot of problems), the myth of metformin as a longevity wonder drug, and Jesse's philosophy on work-life balance with three kids under seven and multiple businesses. His answer to the "best bang for your buck" anti-aging question might frustrate anyone looking for a quick fix: resistance training and staying fit your whole life. Sometimes the unsexy answer is the right one. This episode is essential listening for anyone trying to build a practice that's both profitable and principled.

• (00:00) - Welcome to Botox Cowboys
• (00:14) - Introducing Dr. Jesse Thompson
• (01:58) - The Aesthetics Journey
• (09:28) - Integrative Medicine
• (14:48) - Peptides
• (18:34) - Metformin
• (20:18) - The Canadian Healthcare System
• (23:54) - Being a Guy in a Female Dominated Field
• (25:48) - On Balance