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New Breakthrough: The Neurobiological Basis of Fibromyalgia Pain Revealed

Are you or a loved one struggling with widespread pain often dismissed as stress-induced? Dr. Michael Lenz uncovers groundbreaking data showing that such pain is linked to measurable changes in the brain's structure. This episode delves into a massive study involving over 40,000 participants from the UK Biobank, validating the fibromyalgia index (FMI) as a reliable marker for nociplastic pain, especially seen in fibromyalgia. Key findings spotlight the altered structural connectivity within brain regions like the periaqueductal gray and amygdala, elucidating the link between chronic pain and symptoms such as fatigue and depression. Tune in to grasp a deeper understanding of the biological underpinnings of nociplastic pain and its ramifications for targeted treatments.

Watch on Youtube Here

00:00 Introduction to Nociplastic Pain
01:32 Groundbreaking Study on Fibromyalgia Index
01:52 Understanding Nociplastic Pain and Fibromyalgia
02:52 Brain Networks and Pain Modulation
04:08 Key Findings on Structural Connectivity
04:53 Specific Brain Circuits and Symptoms
06:10 Mediation Models and Symptom Domains
07:10 Specificity of the Fibromyalgia Index
07:48 Conclusion and Key Takeaways
08:16 Final Thoughts

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When I started this podcast and YouTube Channel—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That’s why I created this space: to offer education, validation, and hope. If you’ve been told fibromyalgia “isn’t real” or that it’s “all in your head,” know this—I see you. I believe you. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you’ll find trusted, evidence-based insights here, drawn from my 29+ years as an MD.

Please remember to talk with your doctor about your symptoms and care. This content doesn’t replace per...