Drug Stereochemistry: Analytical Methods and Pharmacology

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Drug Stereochemistry: Analytical Methods and Pharmacology

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This comprehensive resource examines the entire field of drug stereochemistry, covering its historical foundation, fundamental concepts, and modern applications, which include both scientific and academic perspectives as well as governmental, industrial, and clinical viewpoints. Key technical areas addressed include analytical methods for enantioseparation—such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and electromigration techniques—and the pharmacological implications of chirality, focusing on the stereoselective aspects of drug transport, protein binding, pharmacokinetics, and pharmacodynamics. Additionally, the text extensively details the legal and regulatory challenges associated with developing and patenting single-isomer chiral drugs, drawing comparisons between regulatory requirements in the European Union, the United States, and Japan.

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