This episode is all about the purisuit to understand and treat metastatic breast cancer. Dr. Martine Piccart and Dr. Lisa Carey delve into the complexities of metastatic breast cancer (MBC), highlighting why it remains one of the most challenging forms of the disease to treat.

We’re fascinated by the microbiome — and for good reason. But how do we protect this invisible ecosystem that plays such a vital role in our health?

From engineering live, programmable therapeutics that disarm dangerous gut pathogens to creating a global “doomsday vault” to safeguard the diversity of human gut microbes, we dive deep into the cutting-edge science shaping the future of microbiome research.

Show notes

1. Ronda, C., Perdue, T., Schwanz, L. et al. Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01453-12.

2. Dominguez-Bello, M.G., Steiger, D., Fankhauser, M. et al. The microbiota vault initiative: safeguarding Earth’s microbial heritage for future generations. Nat Commun 16, 5373 (2025). https://doi.org/10.1038/s41467-025-61008-5

In this episode, we explore zoonotic diseases and their growing impact on global health.

Professor Clare Bryant, sheds light on strategies to vaccinate animals to prevent pathogen transmission into humans. We also delve into the historical context of the disease, the role of vaccines, and the importance of coordinated public health.

Whether you're a public health professional or simply curious about emerging infectious diseases, this episode offers a comprehensive look at the science, challenges, and solutions surrounding zoonotic diseases.