Alzheimer’s doesn’t begin with sudden memory loss. It begins decades earlier with systemic breakdowns that modern medicine continues to miss. And by the time someone is diagnosed with Alzheimer’s, the damage seems full-blown. In this episode, I sit down with Dr. Brad Younggren to discuss why Alzheimer’s is less a mystery of missing science and more a failure of how our healthcare system is designed.

We explore therapeutic plasma exchange (TPE) and why removing harmful inflammatory proteins, immune antibodies, plastics, and toxic exposures from the bloodstream may represent a powerful new frontier in brain health, longevity, and chronic disease care. Dr. Younggren shares how this decades-old hospital procedure is being safely re-engineered for outpatient use and why it’s showing promise for dementia, autoimmune illness, and accelerated aging.

We also discuss why the exposome, the total toxic burden from plastics, heavy metals, mold, and environmental chemicals, plays a far bigger role in cognitive decline than most people realize. From immune modulation to biological age reversal, this conversation challenges the idea that Alzheimer’s is inevitable or untreatable.

If you care about preventing cognitive decline, extending brain healthspan, and understanding why the medical system often fails Alzheimer's patients, this episode opens your eyes to what’s possible.

Interested in receiving TPE with Dr. Josh? Apply to work with him here: https://drjosh.com/work-with-dr-josh/

“If you reduce the toxic burden on the body, the brain has an incredible ability to heal itself.”

~ Dr. Brad Younggren

In this Episode

00:00 - Introduction to Dr. Brad Younggren of Circulate Health

03:55 - A perspective on therapeutic plasma exchange (TPE)

05:53 - What TPE really is, how it works, and some benefits

15:28 - Immune recalibration and repeat plasma exchange

22:03 - Enhancing the TPE process

28:12 - Biological age reversal and proteomic clocks

31:23 - TPE for Alzheimer’s and dementia

36:37 - Circulate Health’s approach to conducting TPE

38:50 - Minimizing toxin exposure

42:53 - TPE use in emergency rooms and treating specific illnesses

49:29 - The future of TPE study and Circulate Health

Resources:

- Top Supplements for Alzheimer's Guide - https://bit.ly/drjoshguide

Connect with Dr. Brad Younggren:

- Website - https://www.circulate.health/

- LinkedIn - https://www.linkedin.com/company/circulatehealth/

Connect with Dr. Josh Helman, MD:

- Instagram - https://www.instagram.com/greenbrainsMD

- Facebook - https://www.facebook.com/greenbrainsmd/

- LinkedIn -