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BrainSherpa: An Objective Digital Biomarker for mTBI Assessment

BrainSherpa: An Objective Digital Biomarker for mTBI Assessment

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This systematic review and meta-analysis examines neuromechanical probabilistic models used for characterizing mild traumatic brain injury (mTBI), focusing on the role of the BrainSherpa reaction time (RT) as a potential diagnostic and prognostic metric. Findings suggest RT is a promising non-invasive digital biomarker, although current models require refinement and standardization to address variability and enhance clinical utility. The review highlights the potential of integrating these models into clinical practice, sports safety, and rehabilitation protocols to improve patient outcomes.

Based on the sources, reaction time (RT) can be effectively integrated into standardized mild traumatic brain injury (mTBI) assessment protocols by leveraging advancements in sensor technology, improving experimental frameworks, utilizing sophisticated modeling techniques, and adopting a multimodal approach

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