If you’ve been waiting for us to venture back to the land of semiconductors, you’re in luck! On our NVIDIA and TSMC episodes, we explored two components of the silicon value chain: the fabless chip companies that design chips and the foundries that manufacture them. Today, we dive into the software that powers it all, the field electronic design automation (EDA). This is essentially the software that enables chip designers to do their jobs, which has changed dramatically with the rise of AI.

This interview is with two people who understand that world better than anyone: Aart de Geus, the co-founder and Executive Chair of Synopsys, and Sassine Ghazi, Synopsys’s CEO and President. Aart founded the company in 1986, and was CEO until January 2024 when he handed the reins to Sassine. Synopsys is now worth $80 billion, with virtually every chip company as a customer or partner for everything from AI to 5G to automotive. Aart and Sassine talked with us about the future Moore’s Law, where chip makers are finding efficiencies today, how we got here, plus a bonus section on simulation and their $35 billion acquisition of Ansys. Enjoy!

Sponsors:

• Quartr

On our Novo Nordisk episode, we covered the business of Ozempic, the GLP-1 taking the world by storm. On this episode, we dive into the science of the molecule semaglutide (and its predecessor liraglutide) with the world expert on the topic, Lotte Bjerre Knudsen. Lotte is Novo Nordisk’s Chief Scientific Advisor, and led the research group back in the early 1990s that first invented the molecule. A few topics from our conversation:

• The science behind what is happening in the body that causes weight loss while on Ozempic
• What it was like in the 1990s and 2000s believing in a drug for a problem that the rest of the industry (including her own company) had written off
• How weight loss was actually a goal from the very start — not just a side effect of diabetes medication like you often read today!

Sponsors:

• Quartr

We’re joined by Imprint cofounder and Thrive General Partner Gaurav Ahuja to dive deeper into the modern payments ecosystem and Visa’s current place within it. Gaurav was one of our research sources for the Visa episode, and we wanted to bring his insights to you all too. We discuss whether Visa really should be worried about eroding interchange fees, the impact of realtime payments systems, opportunities for startups and whether the Visa / Mastercard duopoly could really be overthrown. Tune in and enjoy!

Links:

• https://www.federalreserve.gov/paymentsystems/files/Avg_IF_by_PCN.pdf

Sponsors:

• Quartr