51. Tripping in Your Sleep: Psychedelics, The Placebo Effect, & How Human Connection Heals the Brain with Dr. Boris Heifets cover art

51. Tripping in Your Sleep: Psychedelics, The Placebo Effect, & How Human Connection Heals the Brain with Dr. Boris Heifets

51. Tripping in Your Sleep: Psychedelics, The Placebo Effect, & How Human Connection Heals the Brain with Dr. Boris Heifets

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 On episode 51 of A Chat with Uma, I sit down with Dr. Boris Heifets, MD, PhD—associate professor at Stanford, anesthesiologist, neuroscientist, & one of the most extraordinary scientists & clinicians who is truly revolutionizing mental health! He pushes the boundaries of how we approach consciousness, mental health, & pharmacology—asking questions most people are too afraid to traverse: Do we need to be awake for drugs to heal the brain? What exactly are ketamine, MDMA, & psilocybin doing when they flip a circuit? Could anesthesiology itself hold keys to psychiatry’s future?And yet what makes Boris remarkable isn’t only the science—it’s who he is. Over two hours, he shares not just his cutting-edge research but his story: moving from Moscow to the U.S., struggling with belonging, discovering MDMA & LSD in college, & how those experiences of connection still shape his lab’s vision today. We explore MDMA for OCD & autism, the limits of “magic bullet” thinking, why context & lifestyle matter more than a single intervention, & how anesthesiology lets him practice applied neuroscience in real time. If you want to understand where psychiatry is heading & hear from one of field's foremost minds, this is an episode you cannot miss.Topics Discussed (+ Timestamps):(00:00:00) Introduction & welcome to Dr. Boris Heifets, MD, PhD!(00:08:44) How Boris & I first met, & why I've admired him since!(00:11:00) Who Boris is beyond titles: curiosity, sci-fi imagination, & breaking boundaries(00:16:00) Childhood across Moscow, Denver, St. Louis, Philly → disconnection & search for belonging(00:17:30) College discoveries: MDMA & LSD → the shock of true connection(00:19:30) MDMA for autism spectrum: Alicia Danforth’s trial & showing connection for the first time(00:22:00) Psychedelics as tools, not cures → lifestyle & comorbidities vs. one-day interventions(00:27:00) How reductionistic models fail to capture what psychedelics actually do(00:31:00) Anesthesiology + psychiatry + neuroscience → how Boris integrates it all(00:36:40) Applied neuroscience: giving drugs, flipping brain states in real time(00:43:00) Why mental health was always his focus & the bottlenecks of human communication(01:00:00) Translational bridge: MDMA, ketamine, psilocybin across mice & humans(01:12:00) What anesthesiology teaches psychiatry about states, context, & timing(01:25:00) Team science vs. lone-genius myth → collaboration, controversy, courage(01:36:00) What makes psychedelic medicine powerful: bending life trajectories, not instant cures(01:45:00) How to measure outcomes when the drug is just the beginning(01:55:00) Risks, hype, & how to ground the field in reality without losing hope(02:10:00) Closing reflections: radical curiosity, gratitude, & staying human in the scienceConnect with Dr. Boris Heifets!Heifets Lab WebsiteRead Boris' publications hereEmailX/Twitter: @TheBorisLabLinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠Try CURED Nutrition's CBN Night Oil, Serenity Gummies, & all of their other fantastic products--Use code 'UMA' for 15% off of all products!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Try CLEARSTEM's amazing skincare products, including VITAMINSCRUB, CELLRENEW, CLEARITY, HYDRAGLOW, and HYDRABERRY--Use code 'UMA' for 15% off all products!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Connect with me!My website⁠: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠umarchatterjee.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok:⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@UmaRChatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Email: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠hello@umarchatterjee.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Support my work: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://ko-fi.com/umarchatterjee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Have a guest request? Fill out the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Guest Suggestion Form!⁠
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