The 49ers' health woes continued after San Francisco lost superstar linebacker Fred Warner to a season-ending ankle injury in Sunday's loss to the Tampa Bay Buccaneers. San Francisco responded valiantly, managing to stay competitive throughout the matchup before fading late in the fourth quarter. Baker Mayfield and the Bucs' high-powered offense proved to be too much in the end as the 49ers suffered their second loss of the season. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan discuss the potential ramifications of Warner's season-ending injury. They then detail Warner's impact on the 49ers organization from ownership to players and how San Francisco will feel his loss both on and off the field. Finally, they deliberate if Warner's injury signifies the beginning of the end in what started out as a promising 49ers' season?

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(1:00) Fred Warner's season officially ends
(2:00) Warner's injury might be the most significant injury in Shanahan-Lynch era
(5:00) Warner might be the NFL's best player, the whole league loses when he's out
(8:00) Hard to ignore the similarities between HOF Patrick Willis and Fred Warner
(9:00) If Warner were to retire today, he might already be HOF-worthy
(11:00) Tatum Bethune steps into Warner’s roll - has strong relationship with Dee Winters already
(14:00) Now is the time for these young players to grow up in a hurry
(16:00) Without Warner the expectations of this team might need to be adjusted
(21:00) Mac Jones-Kendrick Bourne connection continues to produce
(22:00) Jennings-Shanahan altercation might be a storyline to continue to watch
(26:00) What is behind 49ers' run-game issues?

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Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 6 matchup vs. the Tampa Bay Buccaneers and how rookie defensive lineman Alfred Collins has made significant strides this season. Also Greg Papa joins Matt to discuss what QB3 Adrian Martinez will bring to 49ers' offense if Mac Jones gets injured on Sunday.

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(10:18) Kyle Shanahan discusses 49ers taking advantage of long week to recharge
(15:41) Shanahan shares the improvements he’s seen in rookie Alfred Collins
(19:37) Matt, Shanahan discuss the intangibles Mac Jones brings to 49ers
(20:38) Shanahan details how Christian McCaffrey’s unselfish play elevates 49ers
(32:45) Greg Papa discusses QB3 Adrian Martinez’s fit in 49ers' offense (37:33) Matt, Papa previews 49ers-Buccaneers matchup
(38:25) Papa believes Baker Mayfield's play will be key to Buccaneers' performance (45:22) Papa details how 49ers’ injuries at key receiving positions have affected the run game (48:39) Matt, Papa discuss where the Bucs and 49ers fit in the NFC hierarchy entering Week 6

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Star 49ers running back Christian McCaffrey is off to a hot start offensively this season, showing shades of his 2023 AP Offensive Player of the Year campaign. McCaffrey sits down with Matt Maiocco to discuss a plethora of topics, such as learning route-running from his Super Bowl-winning father, identifying the most valuable asset in professional football and describing how George Kittle helps bring "fun" back into the game. Also, Jennifer Lee Chan stops by to update the 49ers' lengthy injury list and preview the potent Buccaneers offense San Francisco will face in Week 6, led by quarterback Baker Mayfield.

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(3:00) 49ers and Bucs are very similar opponents
(7:00) Malik Mustapha returns from ACL surgery
(10:00) 49ers' lengthy injury updates
(28:00) Christian McCaffrey 1-on-1 interview
(34:00) Was CMC pressured to be receiver like dad?
(39:00) CMC describes benefits of "competitive stamina"
(41:00) CMC details the most valuable assets in football
(43:00) CMC pinpoints 49ers' elite leadership structure, from staff to players
(45:00) CMC describes how George Kittle brings "fun" to football

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Matt Maiocco shares the 49ers’ injury update before sitting down with Greg Papa to recap San Francisco’s thrilling 26-23 overtime win over the Los Angeles Rams on Thursday night at SoFi Stadium and discuss how the victory can set the tone for the rest of the season.
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(2:25) Matt shares 49ers’ postgame injury updates
(5:03) George Kittle not likely to be available Week 6
(6:10) Matt recaps 49ers’ thrilling 26-23 overtime win
(11:30) Matt, Greg Papa break down 49ers’ road win over Rams
(15:30) Papa impressed with Mac Jones’ toughness, playmaking
(19:23) Papa credits Kyle Shanahan’s game plan for Week 5 win
(21:28) Matt, Papa evaluate 49ers’ game-winning defensive stop (27:07) Matt, Papa discuss Alfred Collin’s impressive performance vs. Rams

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An injured 49ers squad defied the odds and dug deep for a 26-23 overtime win over the Los Angeles Rams on Thursday at SoFi Stadium. Backup quarterback Mac Jones delivered his third win in three starts despite laboring through pain all game. Kyle Shanahan managed a very limited and at times inexperienced San Francisco squad, and rookies produced when their numbers were called. Matt Maiocco and Jennifer Lee Chan discuss how the 49ers have set themselves up well in the division with an undefeated start, and if a character-defining win like tonight can catapult them to their larger goals despite the early adversity they've experienced thus far.

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(1:30) On paper, 49ers had little chance to win
(3:00) Mac Jones labors through injuries
(4:30) Jones-Bourne connection on full display
(10:30) Where does this rank among Shanahan's best coaching jobs?
(20:00) 49ers' O-line holds up against one of the NFL's best
(26:00) 49ers set themselves up nicely in West
(29:00) Is there a QB controversy in SF?

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John Lynch joins Matt Maiocco to break down the 49ers' first four games of the 2025 NFL season, from how San Francisco's rash of injuries affect his front-office priorities to some of the more positive on-field developments during their resilient start. Jennifer Lee Chan also joins Matt to preview the 49ers' Week 5 matchup vs. the NFC West rival Los Angeles Rams this Thursday at SoFi Stadium, and points out an area of vulnerability San Francisco could expose on a short week against a very potent opponent.

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(1:00) Quick turnaround week vs. Rams
(3:00) 49ers still banged up at two key positions
(6:00) Stats offer different perspective on 49ers' struggling pass rush
(10:00) Rams' defensive line set up to show out in prime time
(17:00) Is it too risky to play injured Brock Purdy again?
(25:00) Area of vulnerability 49ers can take advantage of vs. Rams
(26:00) John Lynch 1-on-1 interview

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An afternoon of errors resulted in the 49ers' first loss of the 2025 NFL season Sunday against the Jacksonville Jaguars. Despite a second-half comeback attempt, San Francisco couldn't overcome its four turnovers. Brock Purdy's looked shaky in his return from injury after missing the last two weeks with turf toe. Matt Maiocco and Jennifer Lee Chan discuss how a subpar performance from all three phases contributed to the 49ers' first defeat. Matt and Jennifer also address the curious postgame exchange between 49ers defensive coordinator Robert Saleh and Jaguars coach Liam Coen as the topic of sign-stealing could be a season-long storyline.

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(1:00) Thursday night matchup vs. Rams gives 49ers chance to turn the page quickly
(4:00) Brock Purdy looked out-of-sync, but dropped passes didn't help
(6:00) Is the lack of takeaways or red-zone woes the bigger concern?
(15:00) Nick Bosa’s gravity on field and locker room noticeably missed in one game without him
(21:00) The defensive line will need to step it up
(31:00) Robert Saleh vs. Liam Coen sign-stealing saga

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Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 4 matchup vs. the Jacksonville Jaguars and also discusses Nick Bosa’s season-ending ACL injury. Greg Papa joins Matt to discuss defensive coordinator Robert Saleh’s comments about the Jaguars’ signal stealing and Brock Purdy returning from injury.

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(7:17) Kyle Shanahan discusses 49ers’ gritty wins to start 2025 NFL season
(10:46) Shanahan shares reaction to Eddy Piñeiro’s winning kick vs. Cardinals
(11:40) Shanahan recalls ‘stages of grief’ after Nick Bosa’s injury
(15:15) What makes Bryce Huff such a great fit for Robert Saleh’s scheme?
(25:52) Why Shanahan believes Week 4 matchup vs. Jaguars is ‘must-win’ for 49ers
(29:04) Greg Papa discusses Saleh’s comments regarding Jaguars’ signal stealing
(38:00) Matt, Papa discuss Brock Purdy returning from injury in Week 4
(42:27) Can a Purdy-led offense pick up the slack for the 49ers' defense after Bosa’s season-ending injury?

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