今日代谢学最高分文献 - 2025-10-31 cover art

今日代谢学最高分文献 - 2025-10-31

今日代谢学最高分文献 - 2025-10-31

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 科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Circulation Research (IF: 16.5)上的重要研究"YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity"。这项突破性研究发现，右心房成纤维细胞比其他心室更具糖酵解活性且YAP活性更高。研究揭示YAP激活会诱导糖酵解，进而驱动纤维化，同时破坏成纤维细胞谱系保真性，使其向骨软骨祖细胞状态转变。更令人惊讶的是，YAP通过激活CSF1分泌促进巨噬细胞扩张，而巨噬细胞又分泌IGF1进一步增强成纤维细胞增殖和纤维化。通过抑制糖酵解或阻断巨噬细胞扩张，研究人员成功减轻了纤维化进程，为心脏纤维化治疗提供了全新靶点，有望改变心力衰竭等疾病的治疗格局。
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