Stark Enterprises has unleashed the Infinite Engine, which promises to be an energy source unlike anything ever seen before. But saboteurs from both A.I.M. and Hydra have set their sights on the engine as well - along with Dr. Doom. When a respected scientist is killed and the Engine taken over, Spiderman and Iron Man join forces to safeguard the Infinite Engine - and all of humanity.

While visiting Japan, Wolverine is recruited to recover a stolen experimental drug, one that has the potential to be a true miracle cure for all human disease - or a sadistic means of enslaving the world. With every hour bringing mankind closer to tragedy, he embarks on a daring mission to identify the thieves and thwart their terrifying agenda.

The X-Men are mutants—born with extraordinary powers that set them apart from the very humanity they are sworn to protect. Now, groundbreaking research has revealed a method for reversing the genetic mutation responsible for mutant powers—whether the mutant wants it reversed or not. The US government wants to use this procedure to eliminate the so-called mutant menace once and for all—but the X-Men soon learn that the true source of the procedure is their old enemy, Sinister! And his agenda is far more complex and dangerous than even the X-Men can imagine.

Magneto, the X-Men's oldest, deadliest foe, has taken over a top-secret government installation that houses the Sentinels, powerful mutant-hunting robots. The X-Men must fight to keep this deadly technology out of Magneto's hands. But the Acolytes, Magneto's fanatical mutant followers, stand between the X-Men and victory - a victory that’s quickly slipping away - for a more ruthless enemy, the US government, holds the X-Men responsible for the installation's takeover!

Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail.