London 1958. Life has moved on since the war, and the youngsters of Mulberry Lane are growing up fast. Peggy’s Ronaski’s family is struggling with growing pains, but she is always there, strong, reliable and ready to help whenever a crisis hits. Meanwhile, Maureen Hart has family problems of her own to contend with. Together they will work hard to conquer all of what life has to throw at them.

Bristol 194. As the clouds of war grow bleaker both at home and abroad, the Tobacco Girls are determined to do their bit for king and country. To that end Maisie Miles and Bridget Milligan become voluntary ambulance drivers. As well as coping with the frequent air raids, Maisie is kept on her toes with three new junior employees, one of whom is particularly testing. Bridget’s heart becomes torn between family loyalty and Lyndon O’Neill III, the man she loves. Meanwhile Phyllis Harvey has joined the WAAF, opting to serve overseas whilst trying to escape her past.

In the face of hardship, Bella Harrison is determined to see the bright side. She is back recording songs with her singing trio The Bryant Sisters, and against all odds, Bella and her husband Bobby are finding ways to muddle through life as newlyweds whilst raising little Levi; Bella’s child with black American pilot Earl Franklin Junior.

Bridget Milligan has donned a uniform and joined the nursing services where she becomes intrigued with the miracles of modern medicine. She’s also torn between family loyalty, her new career and Lyndon O’Neill, the love of her life. Is it too impossible to hope that everything will come out right in the end? Phyllis Harvey is still serving in Malta where she sees the casualties of war first hand. Finally it seems like Phyllis is blessed with true in love, but fate can sometimes be a rocky road and nothing is that certain.

As the Battle of Britain rages, the Castle family are standing their ground at the heart of the community, running Castle's Café. German guns shell Dover and danger lurks around every corner, but despite this, Lily Castle is excited to be starting her nursing career at last. Lily is enjoying her life. She's a good nurse, has a group of friends at the hospital and there is romance on the horizon. That is until her world comes crashing down around her. When she tries to help an injured prisoner of war at the hospital, she ends up implicated in a crime.

1946, Liverpool. Bella Harrison cannot believe the devastating war that stole the lives of her father and sister is truly over at last. She wonders how they will ever rebuild Victory Street with the city in ruins, and half their neighbors gone. But for now, she and her childhood sweetheart, Bobby, are happy newlyweds, doting on Bella’s little son, her child with Black American pilot Earl Franklin Junior. 

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

The Tobacco Girls cling together as they realise that the clouds of war are turning dark, the world is becoming more dangerous and their lives more unpredictable.  Bridget Milligan’s big, happy family fragments when her siblings are evacuated to North Devon, then a letter from America further fills her with dismay. Maisie Miles safe haven from both Eddie Bridgeman and her father is jeopardised, and she is forced to move on, but where to this time? Phyllis Mason is struck down by tragedy, and her life spirals downwards into despair until a new horizons beckons.

Devon, 1918. When Jessie Hale loses her nursing job, she leaves London to become the nurse maid to the Kendle family. On arrival she finds the family in disarray. When their elderly Nanny suffers a bad fall, Jessie has to try to bring the household together. Gradually, Jessie finds her place in their lives. Jessie soon starts to love her life at Kendlebury Hall, but problems arise when her feelings for her employer start to change.... 

For the district nurses of Victory Walk, there's been little time to bask in the triumph of D-day as London is facing a new threat - the buzz bombs. Everyone is terrified, never knowing where the next one will strike. Into this tense atmosphere, new nurse Iris must make her mark. She’s had more experience of nursing than many, but since arriving in East London from the countryside, she has struggled to fit in with the other staff. Meanwhile, Alice is facing an agonising wait to hear if her boyfriend, Joe, has survived D-day.

London 1917. As the Americans enter the war, there is renewed energy in the war effort.  With husbands and sons fighting for freedom, the women of Harpers are left to tackle the day-to-day affairs at home and work. With Ben Harper away, Sally fears she is being followed by a mysterious woman. Who is she, and what does she want? Maggie Gibbs collapses seriously ill in the frontline hospitals and is brought back to England close to death. Can she be saved, and what does the future hold for her and her broken heart? 

Sally Harper is busy juggling running London’s Oxford Street Store Harpers and looking after her beautiful new-born daughter, whilst husband Ben is overseas on another dangerous mission; this time to rescue a friend in need. Young Becky Stockbridge finds herself in a difficult situation, which could bring shame to her and her family. Will Becky, with the help of her friends, find her happy ever after and keep her secret?  Marion Jackson is blessed with a son as she eagerly awaits the return of her husband, Reggie. But all is not right when Reggie returns.

Autumn, 1942. The Blitz has come to an end, but for many families, it's not over yet. As the residents of Jubilee Row begin to rebuild their lives, twins Sybil and Maudie Maguire decide to go off and do their bit by joining the WAAFs. But what starts off as a great adventure soon forces the girls to grow up as they are confronted with the harsh realities of war. Will they stick together, or will their experiences drive them apart? Back in Hull, their older sister, Ada, faces struggles of her own as she nurses the war wounded. But can anyone help to mend her own broken heart?

As a small child, Nellie Peace was always dreaming but sensed her mother’s rejection. Abandoned and sent into service at Beaumont House at an early age, Nellie is lost and alone until she meets the unpredictable and reclusive artist Lucas Harrington and falls in love with him. This unlikely association between master and servant is encouraged by Lucas’ gentle-natured Aunt Alice, as Lucas sees something unusual in Nellie and is compelled to paint her. Broken promises lead to inevitable heartbreak, and Nellie flees Beaumont House in disgrace for London.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth.