Set in the turbulent years following the death of Lorenzo de' Medici, George Eliot's fourth novel, Romola, moves the stage from the English countryside of the 19th century to an Italy four centuries before her time. It tells the tale of a young Florentine woman, Romola de' Bardi, and her coming of age through her troubled marriage to the suave and self-absorbed Greek Tito. Slowly Tito's true character begins to unfurl, and his lies and treachery push Romola toward a more spiritual path, where she transcends into a majestic, Madonna-like role.

Meeting by chance at a gambling hall in Europe, the separate lives of Daniel Deronda and Gwendolen Harleth are immediately intertwined. Daniel, an Englishman of uncertain parentage, becomes Gwendolyn's redeemer as she finds herself drawn to his spiritual and altruistic nature after a loveless marriage. But Daniel's path was already set when he rescued a young Jewess from suicide.

Dorothea Brooke is an ardent idealist who represses her vivacity and intelligence for the cold, theological pedant Casaubon. One man understands her true nature: the artist Will Ladislaw. But how can love triumph against her sense of duty and Casaubon’s mean spirit? Meanwhile, in the little world of Middlemarch, the broader world is mirrored: the world of politics, social change, and reforms, as well as betrayal, greed, blackmail, ambition, and disappointment.

The Portrait of a Lady is the story of a spirited young American woman, Isabel Archer, who "affronts her destiny" and finds it overwhelming. She inherits a large amount of money and subsequently becomes the victim of Machiavellian scheming by two American expatriates. Like many of James' novels, it is set mostly in Europe, notably England and Italy.

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