In the fourteenth century, opportunities for women are limited to the home. But spirited young Madlen finds her calling as assistant to the city's trusted midwife, Clara. Working alongside Clara, Madlen develops a surprisingly soothing technique and quickly becomes a talented healer. After Clara's tragic death, Madlen alone rushes to assist the birth of a local nobleman's child. But rather than the joy of birth, Madlen walks into an accusation of murder and witchcraft because of her extraordinary gifts. Forced to flee her own town, she establishes a new identity in the home of her aunt.

Johanna, the oldest of the three Steinmann sisters, has successfully managed the family glassblowing business since her father's death, and her sister Marie's artistic gifts have made their wares unexpectedly famous. But now the livelihood of the town of Lauscha, Germany - known around the world as the "paradise of glass" - is in danger. The local glassworks is about to be sold, and rumor has it the buyer wants to make changes that will challenge glassblowing tradition.

Despite all that Clara Berg has achieved as a wife, mother, and chemist - especially for a woman in turn-of-the-century Berlin - ending her abusive marriage comes at great cost. The judge hands her inheritance - her parents' pharmacy - over to her ex-husband. Now, with her reputation in near ruins thanks to the scandal that rocked her marriage, no reputable chemist will hire her. Worst of all, she has lost all rights to her young son and daughter.

Tempestuous and beautiful Wanda Miles, daughter of Ruth and Stephen Miles (or so she thinks), aspires to more than the life of a debutante, but the trouble is she doesn't know precisely what she wants. Then her aunt Marie, the family's renowned glassblower, arrives from Lauscha, Germany, and Wanda decides that learning about her ancestry may hold the key to her future. When Marie accidentally reveals a long-held secret about Wanda's parents, Wanda goes to Lauscha to unravel the truth.

Cologne, 1351: Elisabeth and Stephen Hardenstein are twins, but they could not be more different. While Elisabeth is inspired by the family business, absorbing everything her father shows her about the cloth trade, Stephen enjoys a leisurely life and pays little attention to their father's teachings. Elisabeth recognizes her true vocation as a tradeswoman, and though the odds are stacked against her, she pursues her passion.