Burra District Hospital's maternity unit is under threat and will close for births unless a new obstetrician can be found. Midwife Noni Frost needs a miracle. A single mum, Noni lives with her young son, Harley, and her Aunt Win, a free spirit and the beating heart of Burra Guest House. Noni's world is disrupted when Iain McCloud and his pregnant teenage daughter Jacinta move into the guesthouse to await the birth of her baby. There's instant chemistry between Iain and Noni, although he has no plans to stay on in town. 

Sienna Wilson is living her dream in the city - a rewarding obstetrics job in a leading hospital, an apartment with a view and handsome Sergeant McCabe on call whenever she needs him. The last thing she wants is a posting to a remote outback town to investigate a medical mystery. But on arrival in Spinifex, Sienna is brought to life in new and exciting ways. In a community riddled with secrets, she meets troubled young barmaid Maddy, and tough publican Alma, both with their troubles to hide.

When the father she barely knew dies suddenly, midwife Eve Wilson decides she owes it to him to go to the funeral and meet her step-family in Red Sand. After disappointment and heartbreak in Sydney, Dr Callie Wilson doesn't hesitate to move home and spend some time with her grieving mother. Melbourne-based obstetrician Sienna Wilson can't understand why anyone would want to bury themselves in the outback, but when her hospital sends her north to research the medical mystery affecting women in Red Sand, it seems fate is intent on bringing the three sisters together. 

It's been more than 10 years since Maddy Locke left Spinifex, the small outback town where she gave birth to her daughter, Bridget. Now she's back to prove she's got what it takes to run the medical centre and face the memories of that challenging time in her life. But everything's changed - the old pub is gone, her new colleagues aren't pleased to see her and it's drier and hotter than ever.

A year after a tragic accident changed her life forever, Tess Daley is in desperate need of a change. When she is offered a position with the Flying Doctor Service, she seizes the opportunity to make a fresh start. Yet once she arrives in remote Mica Ridge she feels like an outsider, unable to connect with her patients and unsure if she'll ever fit in with this outback community. Station owner Soretta Byrnes has grown to love the company and chaos that comes with living in a house filled with boarders.

Jason Weaver just wants to be left alone. It was a tough transition from his army days to civilian life, and he's looking forward to settling into a solitary life. Tilly Hollis is working two jobs to save for her dream career: running an equine therapy program. Tilly loves her horses more than anything, and after losing her husband and business partner just a few years earlier, she's determined to make it work on her own. When Jason walks into the café where Tilly works, they're immediately drawn to one another. But can they overcome their pasts to find a future together?

Sienna Lewis knows firsthand about being an Aussie battler, but she has her beautiful daughter, Zara, to keep fighting for. One day she dreams of giving Zara the life and big family she deserves. For now, Sienna can only focus on her work at the hospital. But when she connects with a new patient who has driven away nearly everyone in his life, she is astounded when he leaves her his sprawling Far-North Queensland property.

Imogen Bates moved to the small rural town of Gibson's Find to start a new life for herself after the death of her husband. Tired of being haunted by the painful memories of her old life, Imogen set her last remaining hopes on the little town and poured her heart and savings into restoring the Majestic Hotel to its former glory. But while the female-starved town might be glad to see a young woman move in, not everyone is happy about Imogen's arrival. 

Lawson Cooper-Jones has two priorities in life - his son, Ned, and the survival of the dairy farm that has been in his family for generations. Despite the best efforts of the town matchmakers and the determined pursuit of local girl Adeline Walsh, Lawson's heart belongs still, and only, to his late wife. But when a flat tyre strands Lawson and Ned in nearby Rose Hill, he's surprised to find a woman living alone in the old general store of the deserted town. Ned immediately forms a bond with the beautiful stranger called Meg.

Alice Hamilton is enjoying her new life in Ballarat. She's learnt the hard way that knowledge is power and is looking forward to her legal studies, then making a difference as a lawyer with heart. But while Alice's life is looking up, back in Hope Springs the world of her former husband, Rick Peterson, is unravelling. After a chance meeting a few months earlier, Rick and Alice have reconnected. And it's fortunate they have, because Rick is about to need Alice's friendship like he's never needed it before.

After more than 10 years away, Australian soap star Ellie Hughes returns to the small country town of Hope Junction, determined to remain anonymous while caring for her injured godmother, Matilda. But word spreads fast in the tight-knit community. It isn't long before the people of Hope are gossiping about the real reason for Ellie's visit and why she broke the heart of golden boy Flynn Quartermaine all those years ago.

For many years Elizabeth Lawson has battled single-handedly to run the family's historic horse stud in memory of her beloved father. But a devastating loss puts her dreams at risk. With no options left, Liz is forced to turn to her estranged sister Kayla for help. Kayla has built a new life in the city as a wedding planner, far removed from the stableyard sweat and dust of her rural upbringing. She never thought she'd go back. But when Liz calls out of the blue, Kayla forms a plan that could save their childhood home. 

Ashley has recently lost her husband. Daughter Emily is being bullied online. Best friend Nikki is holding a huge secret. And why is husband Chris receiving so many text messages lately? Their teenage children are glued to technology, be it PlayStation, YouTube, Instagram, Snapchat.... The two women hatch a plan: for three weeks, both families will stay in a rustic, remote coastal camp with no phone reception. 

When 25-year-old journalist Zara Ellison receives her mother's ominous text message, 'Call me when you can', Zara knows it's not good news. Two weeks later, Zara has left her much-loved city life to relocate to Barker, the sleepy country town in which she grew up. For Zara, family comes first. But she needs to work too, and the town's police force is a rural journalist's best source of information. Meeting Detective Dave Burrows and Dave's second-in-charge, Senior Constable Jack Higgins, is a priority. 

Nurse Lauren Simpson is known in Hope Junction for the wrong reasons - and she's over it. Watching the man she's always loved marry someone else is the last straw - she decides to get out of Hope. But her resolve is tested when the hot new locum doctor arrives in town. Doctor Tom Lewis also has skeletons in his closet - including a painful breakup and devastating family news. He's hit the road with his vintage ute and surfboard, to travel the outback and live in the moment.