Miles Morales has a lot going on, what with moving to a new neighborhood, dealing with the loss of his father, and the whole gaining superpowers thing. After a misunderstanding with the law, Miles questions what it means to be a hero when people are ready to believe the worst of you. Tempted by the power and freedom of his new abilities, Miles must decide what kind of Spider-Man he wants to be. When Vulture starts wreaking havoc across the city with his new accomplice Starling, Miles can't just sit back and watch.

Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail.

Born to a rarified breed of Russian aristocracy, Kraven the Hunter had stalked and killed every animal known to man and considered himself the world's best big-game hunter. It was this confidence that brought him to New York years ago, in an obsessive quest to hunt what he considered the city's greatest prey: Spider-Man. But his target eluded him time and again, mocking him at every turn.

A vicious serial killer named Cletus Kasady has had his body chemistry altered by an alien creature. Now, Kasady can transform into Carnage, who, along with his lethal living costume, lives for chaos and random acts of senseless, brutal murder! Carnage has been returned to New York in chains, the subject of a daring attempt to reverse the effects of his metamorphosis. When the interference of a deranged scientist causes the experiment to go horribly wrong, Carnage is set loose upon the city once again!

Cyclops and Emma Frost re-form the team with the express purpose of "astonishing" the world. But when breaking news regarding the mutant gene unexpectedly hits the airwaves, will it derail their new plans before they even get started? As demand for the "mutant cure" reaches near-riot levels, the X-Men go head-to-head with the enigmatic Ord, with an unexpected ally - and some unexpected adversaries - tipping the scales!