Within forty-eight hours, Yaya Betancourt will go from discovering teeth between her thighs to being hunted by one of the most powerful corporations in America. She assumes the vagina dentata is a side effect of a rare genetic condition caused by AlphaBeta Pharmaceutical, decades ago, when she and several thousand others were still in the womb.

Siblings Jonah and Nell Talbot used to be inseparable, but ever since Jonah suddenly blew town 12 years ago, they couldn’t be more distant. Now, in the wake of Jonah’s divorce, they embark on a cross-country road trip back to their hometown of Albuquerque, hoping to mend their broken relationship along the way.

Beth and Fran spend their days traveling the ravaged New England coast, hunting feral men and harvesting their organs in a gruesome effort to ensure they'll never face the same fate. Robbie lives by his gun and one hard-learned motto: other people aren't safe. After a brutal accident entwines the three of them, this found family of survivors must navigate murderous TERFs, a sociopathic billionaire bunker brat, and awkward relationship dynamics—all while outrunning packs of feral men, and their own demons.

Episode Thirteen takes them to every ghost hunter's holy grail: the Paranormal Research Foundation. This brooding, derelict mansion holds secrets and clues about bizarre experiments that took place there in the 1970s. It's also famously haunted, and the team hopes their scientific techniques and high tech gear will prove it. But as the house begins to reveal itself to them, proof of an afterlife might not be everything Matt dreamed of.

Alma Katsu calls My Heart Is a Chainsaw “a homage to slasher films that also manages to defy and transcend genre.” On the surface is a story of murder in small-town America. But beneath is its beating heart: a biting critique of American colonialism, Indigenous displacement, and gentrification, and a heartbreaking portrait of a broken young girl who uses horror movies to cope with the horror of her own life.