Times are hard for all on Mulberry Lane as the war rages into yet another year. Desperate times push people into dangerous situations, and the residents of Mulberry Lane are not exempt. Menacing shadows lurk on dark street corners, threatening the safety of those who are alone and vulnerable. When Peggy's twins are born early, Maureen and Nellie are there to lend a helping hand. The mothers of Mulberry Lane stick together despite the grim conditions of war-torn London and a shadowy fear that stalks their lives. Neighbours and friends look out for each other, and new life brings hope and joy to the lane.

1949. Peggy and Able Ronoscki's seaside cafe in Devon is thriving, and their twins, Fay and Freddie, are growing up fast. To pursue her daughter’s destiny, Fay must train in London and Peggy is faced with a dilemma of moving the family back to London once more. Meanwhile, Peggy’s elder daughter, Janet, has her own troubles. She fears her husband is having an affair and is desperately unhappy. Peggy is torn two ways and can only hope that a reunion with her friends at Christmas can help resolve her problems. 

The women of Mulberry Lane anxiously wait for news. Peggy doesn’t know if she’ll ever again see Able, the American father of her twins, while a very odd letter from estranged husband, Laurie, threatens to set the cat among the pigeons. Rose can’t stop loving Jimmy, while Tom can’t stop loving her. Will Gordon ever again be the man he once was? Can he be a proper husband to Maureen, and if he can’t, what will become of their marriage?

Maureen Jackson knew life as a trainee nurse wouldn't be easy, but she didn't expect her hospital to be badly bombed on her first shift. Plus Maureen still has her family and friends in Mulberry Lane to keep her busy - she's needed as much there as she is by her patients. Running the pub on the corner of Mulberry Lane, Peggy Ashley is used to taking in all sorts of waifs and strays. But the arrival of a dashing American captain has got tongues wagging about Mulberry Lane's favourite landlady.... 

Maureen Jackson is a prisoner of her father's blackmail. Three years ago, she'd been hoping to marry Rory, the man of her dreams. However, after her mother's death, Maureen was left to care for her overbearing father. Now Rory is back in London with his pregnant wife and reminds Maureen of the life that should have been hers. With the war looming, Janet Ashley hopes to marry her sweetheart Mike, but her father refuses to grant them his blessing. Janet finds herself pregnant and her mother Peggy is determined to hold her family together.

It is two years since Harpers opened in Oxford Street and Ben is planning to expand the premises. Life is good for Sally and Ben as they look forward to their first child and hope for a prosperous future. Beth is settling into married life with Jack, gradually recovering from her aunt’s tragic death, though still unable to conceive a child. New girls have joined Harpers and Marion, Janice and Becky all become a part of the daily life at the busy store. Rachel is undecided whether to marry a man she isn’t sure she can trust, while Minnie meets an old love.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

The shop girls of Harpers Emporium on Oxford Street are happy in their work, and their lives are moving on at quite a pace. United by the suffragette cause and now living under one roof, some will find love and marriage whilst others experience heartache and tears. Harpers is the bond that holds them together, bringing strength through hardship and pain and friendship and love.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth. 

Liverpool, 1945. As the war draws to a close, Alice and Terry Lomax are building a new life with their young daughter Cathy. After years away fighting, Terry is a stranger to his daughter and must work hard to win her trust and love. Alice and old friend Sadie work in the haberdashery of Lewis’s department store, where bomb damage scars the walls and rationing is still in force. Though memories of those lost in the war are fresh, Alice and Sadie look forward to the future. 

Against the devastating Blitz of London, normal life must continue for Lizzie Larch. With Sebastian returning to war, Lizzie must make a success of her business in order to survive and to care for her young child. Silently in the shadows, her secret enemy watches and waits, threatening to ruin Lizzie and everything she holds close. Lizzie is soon battling against shortages whilst her hat business explodes.... But soon Lizzie begins to realise that success can mean nothing without the man she loves.

London, 1938: Lizzie Larch is a 20-year-old hat maker in London's east end. She is happy and popular, but she carries a secret. Seven years ago she was viciously attacked and recovered in a private sanatorium where she miscarried a child. Lizzie has no memory of the night of the attack, but secrets cannot stay secret for too long. When she starts courting her boss' nephew, a shocking revelation surfaces; threatening to destroy their new-found happiness.

Liverpool, 1955. With her abusive husband drinking all her wages, Alice faces a daily struggle to provide for her family. Her eldest daughter, Cathy, has always longed to be a nurse, but when poverty means she’s forced to leave school and get a job it looks like her dreams are over. But Cathy isn’t willing to give up, and with the support of old friend - and new love - Gianni, she manages to secure a place as a cadet nurse. Now, though, her mam must stand up to her violent husband alone - and with less money coming in, Alice will be in danger of losing everything.

Helen would love to find the courage to tell the dashing Dr Parker of her true feelings for him. But how can she when he clearly has eyes for someone else? More than a year has passed since Bel's wedding to sweetheart Joe. She knows she has much to feel thankful for and yet there is still one burning desire which she cannot ignore. And as Polly grows with child, she hopes against hope for a safe delivery - and that her husband, Tommy, can soon return from the front line to meet their new arrival. 

It’s 1943, and the district nurses have two new recruits. As the country ramps up for D-Day, the new nurses are getting to know their patients on their patch in London’s East End. Lily is quite sure of herself and doesn’t believe she has anything new to learn. She’ll find out the hard way that anyone can be made a fool of when she meets a man who promises her everything.