Jessica Fletcher is quick to accept an invitation to replace a speaker who couldn’t attend a Book Festival in Belfast, Ireland. When her Cabot Cove neighbor Maeve O'Bannon hears about the trip, she asks Jessica to deliver some paintings to her family in the village of Bushmills. Happy to extend her travels and see more of the Irish countryside, Jessica agrees.

Jessica does become somewhat concerned when Bertha Mae starts to talk about her new neighbor, Martin Terranova. Quite charming and very health conscious, Terranova teaches yoga and meditation in his pool house. Maureen Metzger says that she and Bertha Mae became friends in Terranova’s class and mentions how solicitous he is to his older clients. Jessica does become somewhat concerned when Bertha Mae starts to talk about her new neighbor, Martin Terranova. Quite charming and very health conscious, Terranova teaches yoga and meditation in his pool house.

Upon arrival in Edmonton, Jessica is quickly outed as mystery writer J. B. Fletcher, and despite numerous protests, a hotel staffer arranges a book signing for her. This and touristy adventures arranged for the group make for a much busier trip than Jessica was expecting. When a hotel bartender, who also happens to be a stagehand for Emma’s play, turns up dead backstage at the theater, Jessica’s fun and relaxing vacation quickly becomes anything but.

Jessica Fletcher takes up the cause of her good friend Barbara Babs Wirth after Babs's husband Hal suffers a fatal heart attack that Jessica has reason to believe was actually murder. Her suspicions are aroused by a sinister dating site Hal used while he and Babs were having marital issues - a site that might be complicit in somehow swindling him out of millions. Jessica's investigation reveals that Hal was far from the only victim, and when his former business partner is also killed, a deadly pattern emerges.

Jessica Fletcher’s favorite gin-rummy partner, Mimi Van Dorn, checks into the brand-new Clifton Care Partners, a private hospital that’s just opened up shop in town, for a simple procedure - one that leads tragically, and inexplicably, to her death. Seeking justice in her inimitable fashion, Jessica decides to pursue her own investigation of the hospital and its shadowy business dealings. On the trail of what initially appears to be medical malpractice, Jessica digs deeper and learns her friend was actually a victim of something far more sinister.