Upon arrival in Edmonton, Jessica is quickly outed as mystery writer J. B. Fletcher, and despite numerous protests, a hotel staffer arranges a book signing for her. This and touristy adventures arranged for the group make for a much busier trip than Jessica was expecting. When a hotel bartender, who also happens to be a stagehand for Emma’s play, turns up dead backstage at the theater, Jessica’s fun and relaxing vacation quickly becomes anything but.

Jessica Fletcher has had plenty to worry about over her storied career, both as a best-selling novelist and as a part-time sleuth. But she's never had any reason to doubt her longtime publisher and trusted friend, Lane Barfield. When mounting evidence of financial malfeasance leads to an FBI investigation of Lane, Jessica can't believe what she's reading. So when it appears that Barfield has committed suicide, Jessica takes on the task of clearing his name. Sure enough, Jessica turns up several inconsistencies in the case against Barfield, as well as signs he might have been murdered.

Jessica Fletcher is quick to accept an invitation to replace a speaker who couldn’t attend a Book Festival in Belfast, Ireland. When her Cabot Cove neighbor Maeve O'Bannon hears about the trip, she asks Jessica to deliver some paintings to her family in the village of Bushmills. Happy to extend her travels and see more of the Irish countryside, Jessica agrees.

With work on the reconstruction of her beloved home almost complete, Jessica Fletcher is in high holiday spirits, spearheading the annual Christmas parade and preparing for her nephew Grady and his family to come to town. The only thing dampening the holiday cheer is the discovery of two sets of bones on Jessica’s property: one set ancient, the other only about a year old.

Jessica Fletcher’s favorite gin-rummy partner, Mimi Van Dorn, checks into the brand-new Clifton Care Partners, a private hospital that’s just opened up shop in town, for a simple procedure - one that leads tragically, and inexplicably, to her death. Seeking justice in her inimitable fashion, Jessica decides to pursue her own investigation of the hospital and its shadowy business dealings. On the trail of what initially appears to be medical malpractice, Jessica digs deeper and learns her friend was actually a victim of something far more sinister.

After traveling to Bethesda for a mystery writers’ conference, Jessica Fletcher decides she’s earned a vacation and takes a train to Columbia, South Carolina, to visit her old college friend Dolores, who has recently married her third husband, Willis Nickens, a wealthy and cutthroat businessman. They’ve moved into an opulent historic home with plenty of space for guests, and Jessica is ready for a week of shopping, gossiping, and relaxing at the grand estate. But the morning after she arrives, Jessica discovers Willis facedown in the koi pond.

Jessica is delighted when her nephew Grady invites her to spend a few days with his family in an oceanside New York bungalow. But the morning after Jessica’s arrival, Donna finds her boss dead on a tennis court, and Jessica’s dreams of a relaxing visit are quashed. Everyone in the small beachside community is a suspect, and the local authorities—headed by an old colleague of Cabot Cove sheriff Mort Metzger—have asked that no one leave town. Will Jessica be able find a killer and salvage the rest of her trip?

Jessica Fletcher takes up the cause of her good friend Barbara Babs Wirth after Babs's husband Hal suffers a fatal heart attack that Jessica has reason to believe was actually murder. Her suspicions are aroused by a sinister dating site Hal used while he and Babs were having marital issues - a site that might be complicit in somehow swindling him out of millions. Jessica's investigation reveals that Hal was far from the only victim, and when his former business partner is also killed, a deadly pattern emerges.

When Brian Foley is charged with the murder of his next-door neighbour, the fastidious Arthur Cranham, it seems the case against the blustering showman is cut and dried: prints, DNA, CCTV footage - there can't be any doubt. After all - Brian and Arthur have famously been at war for years. But Jack and Sarah are convinced that the police have it wrong. With time running out, can they prove Brian's innocence and find the real killer? Set in the sleepy English village of Cherringham, the detective series brings together an unlikely sleuthing duo: English web designer Sarah and American ex-cop Jack.

Young Jessica Fletcher’s life couldn’t be more ordinary. She teaches at the local high school while she and her loving husband, Frank, are raising their nephew Grady together. But when the beloved principal dies under mysterious circumstances, Jessica knows something is off and, for the very first time, investigates a death. Present-day Jessica returns to high school for a colleague’s retirement party and has fun seeing familiar faces. That is, until the colleague winds up dead - and his death has mysterious links to Jessica’s very first murder case.