Bridget Milligan has donned a uniform and joined the nursing services where she becomes intrigued with the miracles of modern medicine. She’s also torn between family loyalty, her new career and Lyndon O’Neill, the love of her life. Is it too impossible to hope that everything will come out right in the end? Phyllis Harvey is still serving in Malta where she sees the casualties of war first hand. Finally it seems like Phyllis is blessed with true in love, but fate can sometimes be a rocky road and nothing is that certain.

The Tobacco Girls cling together as they realise that the clouds of war are turning dark, the world is becoming more dangerous and their lives more unpredictable.  Bridget Milligan’s big, happy family fragments when her siblings are evacuated to North Devon, then a letter from America further fills her with dismay. Maisie Miles safe haven from both Eddie Bridgeman and her father is jeopardised, and she is forced to move on, but where to this time? Phyllis Mason is struck down by tragedy, and her life spirals downwards into despair until a new horizons beckons.

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

London 1958. Life has moved on since the war, and the youngsters of Mulberry Lane are growing up fast. Peggy’s Ronaski’s family is struggling with growing pains, but she is always there, strong, reliable and ready to help whenever a crisis hits. Meanwhile, Maureen Hart has family problems of her own to contend with. Together they will work hard to conquer all of what life has to throw at them.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Lady Joanna Harcourt and her daughter, Sarah, discover their life of luxury at Goodwill House is over. Because with Lord Harcourt away fighting, the Harcourt girls are facing financial ruin. Lady Joanna is terrified of losing their home, but for Sarah, this means her dreams of becoming a doctor are over. Headstrong Sarah isn’t one to quit! War or not, she’s determined to find a way to save her home and follow her dreams - whatever it takes.

In the face of hardship, Bella Harrison is determined to see the bright side. She is back recording songs with her singing trio The Bryant Sisters, and against all odds, Bella and her husband Bobby are finding ways to muddle through life as newlyweds whilst raising little Levi; Bella’s child with black American pilot Earl Franklin Junior.

Jane Hadley has nothing to lose when she runs away to join the Women's Auxiliary Air Force. Whatever faces her in war-torn London can't be any worse than staying at home with her abusive father. The city is nothing like she could have imagined, but she's soon on the move, travelling from base to base for her top-secret training. Making plenty of friends along the way, it doesn't take long for Jane to embrace her growing confidence - especially under the attentive eye of dashing Officer Oscar Stanton.

As the Battle of Britain rages, the Castle family are standing their ground at the heart of the community, running Castle's Café. German guns shell Dover and danger lurks around every corner, but despite this, Lily Castle is excited to be starting her nursing career at last. Lily is enjoying her life. She's a good nurse, has a group of friends at the hospital and there is romance on the horizon. That is until her world comes crashing down around her. When she tries to help an injured prisoner of war at the hospital, she ends up implicated in a crime.

For the district nurses of Victory Walk, there's been little time to bask in the triumph of D-day as London is facing a new threat - the buzz bombs. Everyone is terrified, never knowing where the next one will strike. Into this tense atmosphere, new nurse Iris must make her mark. She’s had more experience of nursing than many, but since arriving in East London from the countryside, she has struggled to fit in with the other staff. Meanwhile, Alice is facing an agonising wait to hear if her boyfriend, Joe, has survived D-day.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth. 

As Christmas approaches, Alice, Edith and Marg continue to face hardships growing up on one of the poorest streets in Blackpool. Penniless, their friendship has helped them survive this far, but it'll take more than that to see them through the dark days that lie ahead.... Newly married Alice receives shocking news about her pregnancy that threatens the future she's always dreamed of. Marg is struggling to care for her ailing mother and ensure her little sister receives the education she deserves. Edith is grieving the loss of her family while preparing to marry her sweetheart. 

Following a humiliating experience involving the man she thought she’d marry, Iris Tredwick signs up to the Wrens in order to escape and - hopefully - find ‘the right sort’ of man to please her mother. After a bumpy start, Iris manages to befriend outspoken Mary and dreamer Sally as they are sent to their first posting - in Orkney. There she meets engineer Rob, whose flirtatious nature both charms and confounds straight-laced Iris. Much more appropriate for her is local doctor Stewart, if only she felt the same spark for him as she does for Rob.

Even in wartime, East End girl Nancy Evans has reason to hope. She's a rising star in the Women's Auxiliary Air Force, and she'll be walking down the aisle any day now...but then a brutal night of bombing changes her life forever. Newly pregnant and single, Nancy swaps her blue uniform for a pinny, taking on housekeeping duties for handsome village doctor David Denny. And though Nancy tries to stay cheerful and contribute to the war effort in any way she can, it isn't long before she finds herself leaning on David for comfort....

The railway girls have survived unsettling times, and while the bombings might have eased, their own turmoil has only just begun. With Christmas fast approaching, will their wishes come true?