When Ann Rutherford's husband dumps her for the bimbo in his office, unfairly leaving her without a home or a job, she reluctantly joins forces with Rhonda DelMonte to convert Rhonda's Florida seaside estate into the small upscale hotel it once was. Ann, quiet and reserved, is no match for brash, bossy Rhonda, who left the family's New Jersey butcher business after she won the Florida lottery.

Three talented women brought together by a man’s love...When Rose Macklin is asked to help Alec Thurston, the one man she’s ever truly loved, by coming to Palm Desert, California, she doesn’t hesitate. He’s dying of cancer and needs her help overseeing the sale of his hotel, the Desert Sage Inn, to another hotel group. With her marketing skill and as the owner of a very successful blog, she’s his perfect choice to make the sale a smooth transition while ensuring the new owners will maintain the reputation and image of the upscale property after the sale.

When Sukie's husband shacks up with her Pilates instructor, her domestic drama becomes the talk of her small Georgia town. Friends from her married life prove fickle, and Sukie hides at home, terrified of encountering the town gossips at the grocery store. Betsy, Sukie's neighbor, invites her to join "Fat Fridays", a weekly gathering at a local café where the women order whatever they crave - no calories counted. Over sausage pizza and sage advice, Sukie gets a grip on her new life.

Two years ago, Noelle North’s then-fiancé left her waiting at the church on Christmas - her wedding day and birthday. Now, she knows she cannot endure another holiday season at home in Boston. At the urging of four women at the assisted-living community where she serves as health director, Noelle decides to rent Seashell Cottage on the Gulf Coast of Florida for the holidays. She meets Silas Bellingham, the cutest seven-year-old boy she’s ever seen, and his great-grandmother, Althea. 

Ellie Weatherby and the four other grandmothers living at Sanderling Cove decide with only two great-grandchildren, it’s time to swing into action. They invite their grandchildren to spend the summer at the cove, hoping to encourage romance between them. Ellie invites all three of her granddaughters to take over the management of the Sanderling Cove Inn so that she and her bridegroom can spend the time traveling in Europe for their honeymoon.