When a beautiful blonde girl is found half-drowned on a beach, she has no memory of who she is or what horrors have left her there. But an article about her in a Brighton newspaper rings alarm bells for beautician Dale, who shows the police photographs of Lotte Wainright. The girls met working on a cruise ship, and their friendship blossomed as they sailed the seas of South America, until Lotte fell under the sinister influence of an older American couple.

When nine-year-old orphan Georgia James is unexpectedly fostered by the kindly Celia and her bank manager husband, she can hardly believe her luck. But then - on her 15th birthday - she suffers the cruellest betrayal of all at the hands of her foster father and is forced to run away, leaving everything she loves behind.

Lancashire, 1895. When her controlling stepfather suddenly dies, it seems that Elinor Pendleton finally has a chance of freedom. But her hopes are soon dashed when she learns that the thuggish Jason Stafford has inherited every penny, and is determined to have Elinor too. Forced to flee with her maid, Maude, Elinor finds shelter with Maude's distant cousin in the remote village on the shore of Jubilee Lake. But Walter Crossley has troubles of his own. Having lost his closest family in a tragic accident, he needs one of his grandsons to return from America to inherit his farm.

Camille is a nurse specialising in supporting families through the difficult decision to donate the organs of their dying loved ones. Camille's mother is a gifted but uncompromising transplant surgeon determined to make it in a man's world until her own life falls apart. And Camille herself is a mother to Addie–five years old, critically ill and in desperate need of the very organs her mother and grandmother work with.

In a village in Wiltshire, just off a busy road, Larch Tree Lane winds slowly up a low hill. Among the residents is Maggie Hatherall, full of life despite her advancing years, who worries what she is going to do with her 200-year-old home. Lucia Grey has escaped a bad marriage but her ex is reluctant to let her start a new life free of him. And for architect Corin Drayton, an unexpected inheritance is the start of a complicated family wrangle. From the cottages and farms to the local shop, pub and old manor house, the residents' lives are set to intertwine and relationships bloom.

Lancashire, 1930: Leah Turner's father has been killed in an accident at the laundry, and since her mother died years ago it falls to her to become sole provider for her little sister. But women's wages are half those of men, and pawning the few belongings she has left will keep their vicious rent collector at bay for only a few weeks, so even if she finds a job, they'll lose their home. Out of the blue, Charlie Willcox, the local pawnbroker, offers her a deal.

Bristol 1936. Jenny Crawford has resigned herself to a loveless marriage living hand to mouth with their two children. Like many others, husband Roy struggles to find work at the docks but a chance encounter turns the family's fortunes around. Not only does he get regular work but they are also allocated a council house on Coronation Close on the outskirts of the city. Jenny and the children are overjoyed, this is the fresh start she could only ever dream of. But trouble feels never too far away.

In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

Helicopter pilot Ellie Porter loves her job. Soaring above the Kakadu National Park, she feels freed from the questions around her father’s suicide and the heavy loss of her beloved family farm. But when a search-and-rescue mission on the boundary of the old farm reveals unusual excavation works, Ellie vows to investigate. 

In the aftermath of a heartbreaking accident, Kirsty is shocked to discover that she has inherited a vineyard in Western Australia from Ed James, a lonely old man she befriended at the library. But there is a condition to his legacy: Kirsty must give up her quiet life in England and live at the vineyard for a least one year. How will a shy librarian cope on her own in a strange country? As she is forced to take her life off hold, one thing is certain, everything is about to change for Kirsty.