In the blink of an eye, the small Texas town of Harper Springs is flattened by the worst tornadic system to ever hit the area. Homes are demolished, trees are uprooted, and people are left for dead. Taking cover in a cellar with his son, Ryan Gibson narrowly escapes the storm and gets separated from his wife. He hopes that help will come fast - his child is severely injured and the crippling weather pattern rages on, making them pawns in Mother Nature's game.

Gavin Dolan and Avery Phillips are used to extreme weather. As meteorologists and storm chasers, they have seen large-scale hurricanes and tornadoes firsthand. But when the world is threatened with storm systems that will wipe out mankind–hurricanes and tornadoes larger than anyone has ever seen–they are called on by the government to figure out how to stop devastating systems from forming. Thousands of people have died–millions more will perish.

Clint Redshaw walks into a port facility meeting expecting an ordinary day arguing about the budget. When the shaking starts, he keeps calm. But as the tremors stretch on and on, the ground rips apart, the dock disintegrates, and chunks of land fall into the Strait. When the quake finally ends, there's only one thing on his mind: his daughter. Mika's singing songs and laughing with a gaggle of other sixteen-year-olds as they climb into the Pacific Northwest mountains for a scout weekend. One minute, it's sunshine and good vibes, and the next, it's screaming and chaos.

Young parents Ethan and Brooke Spencer are on a romantic ski vacation in the Rockies when the lights go out, cars stall, and communications fail. Stranded 800 miles from home, they are desperate to return to their four-year-old twins and are willing to do whatever it takes to reach them.

As earthquakes are triggered, fault lines split, buildings crumble, and monstrous tsunamis rush inland, Jax, his daughter Zoe, and a group of civilians with vastly separate lives collide in the Northwest in an interweaving story of survival, loss, and redemption. Meanwhile, Natalie Reid is at the Gatlinburg Midnight Parade, charged with caring for teens from a group home; when the earth shakes, the sky lights up in a brilliant light, and planes fall from the sky.