Harlem, 1926. Young Black women like Louise Lloyd are ending up dead. Following a harrowing kidnapping ordeal when she was in her teens, Louise is doing everything she can to maintain a normal life. She’s succeeding, too. She spends her days working at Maggie’s Café and her nights at the Zodiac, Harlem’s hottest speakeasy. Louise’s friends, especially her girlfriend, Rosa Maria Moreno, might say she’s running from her past and the notoriety that still stalks her, but don’t tell her that.

Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

When professional soccer player Alex Grey goes on a vacation to the local South Carolina islands, she isn't anticipating any life-changing events. Just a relaxing weekend to prepare for the upcoming season. But that quickly changes when she finds herself the lone witness to a sailing accident and makes the decision to risk her own life to save a drowning woman—unwittingly coming to the rescue of a US senator's wife, Catharine Cleveland.

When a young red-haired woman is found brutally murdered in downtown Chicago, one detail stands out: the red lipstick encircling her wrists and ankles. Detective Harriet Foster is on the case, even though she’s still grieving the sudden death of her partner. As a Black woman in a male-dominated department, Foster anticipates a rocky road ahead acclimating to a new team—and building trust with her new partner isn’t coming easily. After another victim turns up with the same lipstick markings, Foster suspects she’s looking for a serial killer. 

Anna Horn is always looking over her shoulder. For the bullies who torment her, for the entitled visitors at the reservation’s casino…and for the nameless, disembodied entity that stalks her every step—an ancient tribal myth come-to-life, one that’s intent on devouring her whole. With strange and sinister happenings occurring around the casino, Anna starts to suspect that not all the horrors on the reservation are old. As girls begin to go missing and the tribe scrambles to find answers, Anna struggles with her place on the rez.