Folate in Health and Disease

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Folate in Health and Disease

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A comprehensive scientific review of folate, examining its biochemical pathways, metabolic regulation, and critical role in human health. It describes how this vitamin acts as a one-carbon donor essential for DNA synthesis, amino acid metabolism, and the prevention of neural tube defects during pregnancy. The sources explore the impact of genetic polymorphisms, such as the MTHFR variant, on disease susceptibility and the effectiveness of folic acid fortification programs worldwide. Furthermore, the material investigates the complex relationship between folate status and chronic conditions, including cardiovascular disease, cancer, and cognitive decline. Finally, the text details various analytical methodologies, such as mass spectrometry and microbiological assays, used to measure folate levels in biological samples and food.

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