Welcome to the ISIR - International Society for Independent Research podcast. In this episode, we delve into the heart of photobiomodulation (PBM). Have you ever wondered how red or near-infrared light can accelerate wound healing or improve cognitive function?

We'll find the answer in an article published in the latest issue of our scientific journal, JIR - Journal of Independent Research, authored by Francesco Rossani and Marisa Roncati.

We'll analyze the fundamental role of mitochondria, the powerhouses of our cells. We'll discover how photons emitted by diode lasers (in the range between 600 and 1100 nm) are absorbed by a specific receptor called cytochrome c oxidase (CCO). This interaction doesn't produce heat, but it triggers a biochemical cascade that increases ATP production (cellular energy), modulates free radicals, and releases nitric oxide to improve circulation.

But beware: in PBM, precision is everything. We'll discuss the Arndt-Schulz Law, or the biphasic dose-response: too low a dose has no effect, the right dose stimulates healing, but too high a dose can paradoxically inhibit cellular processes.

In this episode, we'll delve into:

• Why the diode laser is the tool of choice for this therapy.

• The science behind skin rejuvenation and collagen synthesis.

• The challenges of current research: why standardizing parameters is essential to transform these discoveries into universal clinical protocols.

• The future of light-based personalized medicine.

Don't miss this technical yet accessible journey through biology and optical physics.