The Avengers journey into deep space, where they unite the intergalactic races against the Builders - deadly aliens who seek to destroy the known galaxy. While the heroes are gone, Thanos sets his sights on Earth, sending the Black Order to launch the assault. It falls to the other heroes of Earth - the Inhumans, the Black Panther, Namor the Sub-Mariner, Doctor Strange, the X-Men, and more - to defend Attilan, Wakanda, Atlantis, and the rest of the planet. To defeat Thanos, the defending forces will need to deploy a new weapon - one that may be as deadly as the invading force.

Iron Man and Captain America are two core members of the Avengers, the world's greatest superhero team. But when a tragic battle blows a hole in the city of Stamford, killing hundreds of people, the US government demands that all superheroes unmask and register their powers. To Tony Stark - Iron Man - it's a regrettable but necessary step. To Captain America, it's an unbearable assault on civil liberties.

Miles Morales has a lot going on, what with moving to a new neighborhood, dealing with the loss of his father, and the whole gaining superpowers thing. After a misunderstanding with the law, Miles questions what it means to be a hero when people are ready to believe the worst of you. Tempted by the power and freedom of his new abilities, Miles must decide what kind of Spider-Man he wants to be. When Vulture starts wreaking havoc across the city with his new accomplice Starling, Miles can't just sit back and watch.

Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail.

Stark Enterprises has unleashed the Infinite Engine, which promises to be an energy source unlike anything ever seen before. But saboteurs from both A.I.M. and Hydra have set their sights on the engine as well - along with Dr. Doom. When a respected scientist is killed and the Engine taken over, Spiderman and Iron Man join forces to safeguard the Infinite Engine - and all of humanity.