In a North Carolina mountain town filled with moonshine and rotten husbands, Sadie Blue is only the latest girl to face a dead-end future at the mercy of a dangerous drunk. She's been married to Roy Tupkin for 15 days, and she knows now that she should have listened to the folks who said he was trouble. But when a stranger sweeps in and knocks the world off-kilter for everyone in town, Sadie begins to think there might be more to life than being Roy's wife.

For twelve-year-old Martha "Sonny" Creech, there is no place more beautiful than her family's cotton farm. She, her two brothers, and her parents work hard on their land - hoeing, planting, picking - but only Sonny loves the rich, dark earth the way her father does. When a tragic accident claims his life, her stricken family struggles to fend off ruin - until their rich, reclusive neighbor offers to help finance that year's cotton crop.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.  

Fifteen-year-old Faith Wilson takes her little sister Hope’s hand. In worn-down shoes, they walk through the choking heat of the Dust Bowl, toward a new life in California. But when a storm blows in, the girls are separated from their parents. Starving and forced to sleep on the streets, Faith thinks a room in a small boarding house will keep her sister safe. But the glare in the landlady’s eye, as Faith leaves in search of their parents, has her wondering if she’s made a dangerous mistake. 

For years, the town of Silver Bell, Arkansas has quietly mourned the hospital fire that claimed the lives of nine of its residents—the town doctor, a young expectant mother, and seven infants. So, when journalist Finn Hardwick is assigned the story as part of a national thirtieth anniversary memorial service, he arrives at the town ready to interview its residents, thinking they’ll be ready to share and eager to make headlines. He isn’t prepared for the resistance. Or for what appears to be a collective unwillingness to answer his questions.

Life is hard for Ruby growing up in poverty on the wrong side of the mountain on her grandfather's farm where literally the sun didn’t shine. The Appalachian setting isn’t her friend as she searches for an easy life at the "tippy-top" with contentment and security. Ruby makes a series of bad decisions, causing her life to tumble into an unexpected outcome.

It is 1933 inside a sweltering courtroom in Macon, Georgia. Fifteen-year-old Robert sits on a bench awaiting sentencing after being picked up for vagrancy and spending a night in jail. He left his home in Illinois with a neighborhood friend to ride the rails and find work to help their families. The friend turned back, too afraid to face the perils ahead. But going back empty-handed isn’t an option for Robert.

Wyoming, 1876. For as long as they have lived on the frontier, the Bemis and Webber families have relied on each other. With no other settlers for miles, it is a matter of survival. But when Ernest Bemis finds his wife, Cora, in a compromising situation with their neighbor, he doesn’t think of survival. In one impulsive moment, a man is dead, Ernest is off to prison, and the women left behind are divided by rage and remorse.

MACEY MAY JOHNSON knows something isn't right when her mama puts her alone on a bus to her grandma's farm with strict instructions to wait to be picked up at the station. She's only nine and has never been allowed to travel by herself before, but her daddy is gone and the bills can't be paid. And Macey May knows her family keeps secrets. She can feel it in her bones.

Del Wensley, wife of the most celebrated preacher in Harlan County, tries to mind her place. Until her husband’s infidelity pushes an already strained marriage to a breaking point. Clinging to her last hope for self-respect, Del turns her back on the rigid life she’s known. A coal train is rolling through the valley. With her eyes wide open to the unfamiliar, and to the freedom she craves, Del takes to the rails.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....   

Glass Ferry, Kentucky, is bourbon country. Whiskey has been a way of life for generations, enabling families to provide and survive even in the darkest times. Flannery Butler's daddy, Beauregard "Honey Bee" Butler, entrusted her with his recipes before he passed on, swearing her to secrecy. But Flannery is harboring other secrets too, about her twin sister Patsy, older by eight minutes and pretty in a way Flannery knows she'll never be. Then comes the prom night when Patsy - wearing a yellow chiffon dress and the family pearls - disappears along with her date.

Teeny, Sonny Boy and Vic have been swallowed up by the desperation and devastation of the Great Depression, but the trio is buoyed by the fantastical tales Teeny weaves around campfires in hobo jungles and migrant camps, including the story of the raffle baby. As the three navigate the ravages of poverty and prejudices, they form a family bond as strong as the forces against them. But when a solemn pact fails to protect them, their lives are forever changed. And Sonny Boy is left to tell their story, and his own.

Worie Dressar is 17 years old when influenza and typhoid ravage her Appalachian Mountain community in 1877, leaving behind a growing number of orphaned children with no way to care for themselves. Worie’s mother has been secretly feeding several of these little ones on Sourwood Mountain. But when tragedy strikes, Worie is left to figure out why and how she was caring for them. 

The folks in the Kentucky Appalachians are scraping by. Coal mining and hardscrabble know-how are a way of life for these isolated people. But when Amanda Rye, a young widowed mother and traveling packhorse librarian, comes through a mountain community hit hard by the nation’s economic collapse, she brings with her hope, courage, and apple pie.