Jo Beckett is a forensic psychiatrist who profiles victims' lives to help solve their deaths. On a San Francisco street, she is confronted by a scene of pure carnage: four dead and five injured after a high speed pursuit. In the mangled remains of a BMW lies prosecutor Callie Harding, dead with the word "dirty" written in lipstick on her thigh. Why did Harding run from the police? Why did she crash through a bridge railing? Was it an accident? Suicide? Or murder? Jo is a last resort in difficult cases.
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Forensic psychiatrist Jo Beckett is called to the scene of an aircraft to help deal with an erratic passenger. She figures out that he’s got anterograde amnesia, and can’t form new memories. For every cryptic clue he is able to drag up from his memory, Jo has to sift through a dozen nonsensical statements. Suddenly a string of clues arises, something to do with a deadly biological agent, a missing wife and son, and a secret partnership gone horribly wrong.
Tasia McFarland is a washed-up singer desperate to get back to the top of the charts. As her star begins to rise again, the tabloids uncover the fact that Tasia is the ex-wife of the US president - which is one reason the world takes notice when she is killed by a bullet to the neck in front of a crowd of fans. Suicide is suspected, but when the ballistics report comes up empty, the authorities call on Jo Beckett to do a psychological autopsy. As Jo sifts through the facts, she only finds more questions....