The Age of Death ended countless millennia ago. No longer burdened by limited lifespans, the immortal humans who populate inhabited space now have the luxury to travel vast distances effortlessly and to tinker with the intricate mechanics of space time. But one such experiment in quantum physics has had a catastrophic and unanticipated result, creating an enormous, rapidly expanding vacuum - a region of new physics - with the frightening potential to devour countless inhabited solar systems.

Fraa Erasmus is a young avout living in the Concent of Saunt Edhar, a sanctuary for mathematicians, scientists, and philosophers, protected from the corrupting influences of the "Saecular" world by ancient stone, honored traditions, and complex rituals. Over the centuries, cities, and governments have risen and fallen beyond the concent's walls. Three times during history's darkest epochs, bloody violence born of superstition and ignorance has invaded and devastated the cloistered mathic community.

Investigative reporter Andrew Worth turns down a documentary on a mysterious new mental illness - "Distress," or acute clinical anxiety syndrome, for another assignment. He's on his way to the artificial island of Stateless, where the world's top physicists are gathering to decide on a new TOE, or Theory of Everything, to replace Einstein's outmoded legacy.

In a corporate-dominated spacefaring future, planetary missions must be approved and supplied by the Company. Exploratory teams are accompanied by Company-supplied security androids, for their own safety. But in a society where contracts are awarded to the lowest bidder, safety isn’t a primary concern. On a distant planet, a team of scientists are conducting surface tests, shadowed by their Company-supplied ‘droid—a self-aware SecUnit that has hacked its own governor module, and refers to itself (though never out loud) as “Murderbot.”

In this prequel to Eon, Greg Bear continues to explore the possibilities presented by the asteroid Thistledown, a remnant of a lost human civilization. The Way is a tunnel through space and time that leads to other worlds, some more like planet Earth than Earth itself. It is perhaps the most formidable discovery in Thistledown and with it come disputes as to the nature of the Way and how it should be used. The Way can be reached only through Axis City, the only space station of Thistledown.